Single Low-Density Lipoprotein Apheresis Does Not Improve Vascular Endothelial Function in Chronically Treated Hypercholesterolemic Patients
Objective. To investigate vascular endothelial function (VEF) responses to a single low-density lipoprotein (LDL) apheresis session in hypercholesterolemic patients undergoing chronic treatment. Methods. We measured brachial artery flow-mediated dilation (FMD), plasma lipids, vitamin E (α- and γ-toc...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/4613202 |
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| author | Kevin D. Ballard Eunice Mah Yi Guo Richard S. Bruno Beth A. Taylor Jo Ellen Beam Donna M. Polk Paul D. Thompson |
| author_facet | Kevin D. Ballard Eunice Mah Yi Guo Richard S. Bruno Beth A. Taylor Jo Ellen Beam Donna M. Polk Paul D. Thompson |
| author_sort | Kevin D. Ballard |
| collection | DOAJ |
| description | Objective. To investigate vascular endothelial function (VEF) responses to a single low-density lipoprotein (LDL) apheresis session in hypercholesterolemic patients undergoing chronic treatment. Methods. We measured brachial artery flow-mediated dilation (FMD), plasma lipids, vitamin E (α- and γ-tocopherol), markers of oxidative/nitrative stress (malondialdehyde (MDA) and nitro-γ-tocopherol (NGT)), and regulators of NO metabolism (arginine (ARG) and asymmetric dimethylarginine (ADMA)) prior to (Pre) and immediately following (Post) LDL apheresis and at 1, 3, 7, and 14 d Post in 5 hypercholesterolemic patients (52 ± 11 y). Results. Relative to Pre, total cholesterol (7.8±1.5 mmol/L) and LDL-cholesterol (6.2±1.2 mmol/L) were 61% and 70% lower (P<0.01), respectively, at Post and returned to Pre levels at 14 d. Brachial FMD responses (6.9 ± 3.6%) and plasma MDA, ARG, and ADMA concentrations were unaffected by LDL apheresis. Plasma α-tocopherol, γ-tocopherol, and NGT concentrations were 52–69% lower at Post (P<0.01), and α-tocopherol remained 36% lower at 1 d whereas NGT remained 41% lower at d 3. Conclusions. Acute cholesterol reduction by LDL apheresis does not alter VEF, oxidative stress, or NO homeostasis in patients treated chronically for hypercholesterolemia. |
| format | Article |
| id | doaj-art-73bd9b820b8d40278c6a609074071bb6 |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-73bd9b820b8d40278c6a609074071bb62025-02-03T05:47:18ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322016-01-01201610.1155/2016/46132024613202Single Low-Density Lipoprotein Apheresis Does Not Improve Vascular Endothelial Function in Chronically Treated Hypercholesterolemic PatientsKevin D. Ballard0Eunice Mah1Yi Guo2Richard S. Bruno3Beth A. Taylor4Jo Ellen Beam5Donna M. Polk6Paul D. Thompson7Department of Kinesiology and Health, Miami University, Oxford, OH 45056, USAHuman Nutrition Program, Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USAHuman Nutrition Program, Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USAHuman Nutrition Program, Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USADivision of Cardiology, Hartford Hospital, Hartford, CT 06102, USADivision of Cardiology, Hartford Hospital, Hartford, CT 06102, USADivision of Cardiology, Brigham and Women’s Hospital, Boston, MA 02115, USADivision of Cardiology, Hartford Hospital, Hartford, CT 06102, USAObjective. To investigate vascular endothelial function (VEF) responses to a single low-density lipoprotein (LDL) apheresis session in hypercholesterolemic patients undergoing chronic treatment. Methods. We measured brachial artery flow-mediated dilation (FMD), plasma lipids, vitamin E (α- and γ-tocopherol), markers of oxidative/nitrative stress (malondialdehyde (MDA) and nitro-γ-tocopherol (NGT)), and regulators of NO metabolism (arginine (ARG) and asymmetric dimethylarginine (ADMA)) prior to (Pre) and immediately following (Post) LDL apheresis and at 1, 3, 7, and 14 d Post in 5 hypercholesterolemic patients (52 ± 11 y). Results. Relative to Pre, total cholesterol (7.8±1.5 mmol/L) and LDL-cholesterol (6.2±1.2 mmol/L) were 61% and 70% lower (P<0.01), respectively, at Post and returned to Pre levels at 14 d. Brachial FMD responses (6.9 ± 3.6%) and plasma MDA, ARG, and ADMA concentrations were unaffected by LDL apheresis. Plasma α-tocopherol, γ-tocopherol, and NGT concentrations were 52–69% lower at Post (P<0.01), and α-tocopherol remained 36% lower at 1 d whereas NGT remained 41% lower at d 3. Conclusions. Acute cholesterol reduction by LDL apheresis does not alter VEF, oxidative stress, or NO homeostasis in patients treated chronically for hypercholesterolemia.http://dx.doi.org/10.1155/2016/4613202 |
| spellingShingle | Kevin D. Ballard Eunice Mah Yi Guo Richard S. Bruno Beth A. Taylor Jo Ellen Beam Donna M. Polk Paul D. Thompson Single Low-Density Lipoprotein Apheresis Does Not Improve Vascular Endothelial Function in Chronically Treated Hypercholesterolemic Patients International Journal of Vascular Medicine |
| title | Single Low-Density Lipoprotein Apheresis Does Not Improve Vascular Endothelial Function in Chronically Treated Hypercholesterolemic Patients |
| title_full | Single Low-Density Lipoprotein Apheresis Does Not Improve Vascular Endothelial Function in Chronically Treated Hypercholesterolemic Patients |
| title_fullStr | Single Low-Density Lipoprotein Apheresis Does Not Improve Vascular Endothelial Function in Chronically Treated Hypercholesterolemic Patients |
| title_full_unstemmed | Single Low-Density Lipoprotein Apheresis Does Not Improve Vascular Endothelial Function in Chronically Treated Hypercholesterolemic Patients |
| title_short | Single Low-Density Lipoprotein Apheresis Does Not Improve Vascular Endothelial Function in Chronically Treated Hypercholesterolemic Patients |
| title_sort | single low density lipoprotein apheresis does not improve vascular endothelial function in chronically treated hypercholesterolemic patients |
| url | http://dx.doi.org/10.1155/2016/4613202 |
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