Improving physicochemical, mechanical, and biological properties of a porous polyvinyl alcohol/chitosan matrix via modification with magnesium and silicon agents
Objective(s): Biocomposite scaffolds made from polymers and bioactive materials can provide the necessary bioactivity and mechanical properties for bone tissue engineering.Materials and Methods: In this study, we aimed to evaluate the properties of a novel composite scaffold made from a combination...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2025-07-01
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| Series: | Nanomedicine Journal |
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| Online Access: | https://nmj.mums.ac.ir/article_26009_190afb5077ec84064733d3f32579ff7a.pdf |
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| author | Nima Vakili Azadeh Asefnejad Mohammad Mohammadi Hessam Rezaei Amirsalar Khandan |
| author_facet | Nima Vakili Azadeh Asefnejad Mohammad Mohammadi Hessam Rezaei Amirsalar Khandan |
| author_sort | Nima Vakili |
| collection | DOAJ |
| description | Objective(s): Biocomposite scaffolds made from polymers and bioactive materials can provide the necessary bioactivity and mechanical properties for bone tissue engineering.Materials and Methods: In this study, we aimed to evaluate the properties of a novel composite scaffold made from a combination of chitosan, PVA, MgCl₂, and GPTMS as a crosslinking agent. Scanning Electron Microscopy (SEM) and Fourier-Transform Infrared Spectroscopy (FTIR) analysis characterized the prepared composite scaffold. The composite scaffolds' mechanical properties, bioactivity, biocompatibility, swelling, and degradation were also investigated.Results: Significant improvements in the mechanical properties were observed in the modified composite compared to those seen in the scaffold without MgCl₂. With an increase in MgCl₂ content, the scaffold's degradation and porosity increased, while its swelling capacity decreased. Bioactivity was also enhanced in the composite following the further addition of MgCl₂.Conclusion: In vitro tests for cytotoxicity and MG-63 cell proliferation showed that the composite scaffolds were non-cytotoxic, resulting in better cell adherence and growth on the surface of these scaffolds. |
| format | Article |
| id | doaj-art-734172e9c2944e44b426e8e08a9b26f1 |
| institution | Kabale University |
| issn | 2322-3049 2322-5904 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Nanomedicine Journal |
| spelling | doaj-art-734172e9c2944e44b426e8e08a9b26f12025-08-20T03:58:44ZengMashhad University of Medical SciencesNanomedicine Journal2322-30492322-59042025-07-0112350751710.22038/nmj.2025.79321.195126009Improving physicochemical, mechanical, and biological properties of a porous polyvinyl alcohol/chitosan matrix via modification with magnesium and silicon agentsNima Vakili0Azadeh Asefnejad1Mohammad Mohammadi2Hessam Rezaei3Amirsalar Khandan4Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, IranDental Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, IranObjective(s): Biocomposite scaffolds made from polymers and bioactive materials can provide the necessary bioactivity and mechanical properties for bone tissue engineering.Materials and Methods: In this study, we aimed to evaluate the properties of a novel composite scaffold made from a combination of chitosan, PVA, MgCl₂, and GPTMS as a crosslinking agent. Scanning Electron Microscopy (SEM) and Fourier-Transform Infrared Spectroscopy (FTIR) analysis characterized the prepared composite scaffold. The composite scaffolds' mechanical properties, bioactivity, biocompatibility, swelling, and degradation were also investigated.Results: Significant improvements in the mechanical properties were observed in the modified composite compared to those seen in the scaffold without MgCl₂. With an increase in MgCl₂ content, the scaffold's degradation and porosity increased, while its swelling capacity decreased. Bioactivity was also enhanced in the composite following the further addition of MgCl₂.Conclusion: In vitro tests for cytotoxicity and MG-63 cell proliferation showed that the composite scaffolds were non-cytotoxic, resulting in better cell adherence and growth on the surface of these scaffolds.https://nmj.mums.ac.ir/article_26009_190afb5077ec84064733d3f32579ff7a.pdfpva-chitosan scaffoldsmagnesium chloridegptmsosseoinductivitydental materials |
| spellingShingle | Nima Vakili Azadeh Asefnejad Mohammad Mohammadi Hessam Rezaei Amirsalar Khandan Improving physicochemical, mechanical, and biological properties of a porous polyvinyl alcohol/chitosan matrix via modification with magnesium and silicon agents Nanomedicine Journal pva-chitosan scaffolds magnesium chloride gptms osseoinductivity dental materials |
| title | Improving physicochemical, mechanical, and biological properties of a porous polyvinyl alcohol/chitosan matrix via modification with magnesium and silicon agents |
| title_full | Improving physicochemical, mechanical, and biological properties of a porous polyvinyl alcohol/chitosan matrix via modification with magnesium and silicon agents |
| title_fullStr | Improving physicochemical, mechanical, and biological properties of a porous polyvinyl alcohol/chitosan matrix via modification with magnesium and silicon agents |
| title_full_unstemmed | Improving physicochemical, mechanical, and biological properties of a porous polyvinyl alcohol/chitosan matrix via modification with magnesium and silicon agents |
| title_short | Improving physicochemical, mechanical, and biological properties of a porous polyvinyl alcohol/chitosan matrix via modification with magnesium and silicon agents |
| title_sort | improving physicochemical mechanical and biological properties of a porous polyvinyl alcohol chitosan matrix via modification with magnesium and silicon agents |
| topic | pva-chitosan scaffolds magnesium chloride gptms osseoinductivity dental materials |
| url | https://nmj.mums.ac.ir/article_26009_190afb5077ec84064733d3f32579ff7a.pdf |
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