The X-linked intellectual disability gene CUL4B is critical for memory and synaptic function

The X-linked intellectual disability gene CUL4B is critical for memory and synaptic function

Abstract Cullin 4B (CUL4B) is the scaffold protein in the CUL4B-RING E3 ubiquitin ligase (CRL4B) complex. Loss-of-function mutations in the human CUL4B gene lead to syndromic X-linked intellectual disability (XLID). Till now, the mechanism of intellectual disability caused by CUL4B mutation still ne...

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Bibliographic Details
Main Authors: Wei Jiang, Jian Zhang, Molin Wang, Yongxin Zou, Qiao Liu, Yu Song, Gongping Sun, Yaoqin Gong, Fan Zhang, Baichun Jiang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Acta Neuropathologica Communications
Subjects:
CUL4B
Memory
Synapse
Intellectual disability
Online Access:https://doi.org/10.1186/s40478-024-01903-y
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https://doi.org/10.1186/s40478-024-01903-y

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