The role of skin testing, drug challenge and IFN-γ ELISpot in delayed hypersensitivity to iodinated contrast media

The role of skin testing, drug challenge and IFN-γ ELISpot in delayed hypersensitivity to iodinated contrast media

Abstract Background The use of in vivo and ex vivo diagnostic tools for delayed hypersensitivity reactions (DHRs) associated with iodinated contrast media (ICM) is currently ill-defined. Objective To evaluate the role of in vivo and ex vivo diagnostic tools for DHRs occurring >6 h following intra...

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Main Authors: Ana Maria Copaescu, Kyra Y. L. Chua, Effie Mouhtouris, Natasha E. Holmes, Moneerah AlGassim, Ibtihal Al Otaibi, Florian Stehlin, Ghislaine A. C. Isabwe, Christos Tsoukas, Jean-Francois Toupin, Derek Lee, Moshe Ben-Shoshan, Elizabeth J. Phillips, Jason A. Trubiano
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Allergy, Asthma & Clinical Immunology
Subjects:
Delayed hypersensitivity reactions
Maculopapular exanthema
Drug reaction with eosinophilia and systemic symptoms
Iodinated contrast media
In vivo diagnostic tools
Ex vivo diagnostic tools
Online Access:https://doi.org/10.1186/s13223-025-00982-3
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https://doi.org/10.1186/s13223-025-00982-3

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