Intercellular Mitochondrial transfer: Therapeutic implications for energy metabolism in heart failure
Heart failure (HF) remains one of the leading causes of high morbidity and mortality globally. Impaired cardiac energy metabolism plays a critical role in the pathological progression of HF. Various forms of HF exhibit marked differences in energy metabolism, particularly in mitochondrial function a...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661824005000 |
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| author | Huan He Weiwei Huang Zigang Pan Lingjun Wang Zhongqi Yang Zixin Chen |
| author_facet | Huan He Weiwei Huang Zigang Pan Lingjun Wang Zhongqi Yang Zixin Chen |
| author_sort | Huan He |
| collection | DOAJ |
| description | Heart failure (HF) remains one of the leading causes of high morbidity and mortality globally. Impaired cardiac energy metabolism plays a critical role in the pathological progression of HF. Various forms of HF exhibit marked differences in energy metabolism, particularly in mitochondrial function and substrate utilization. Recent studies have increasingly highlighted that improving energy metabolism in HF patients as a crucial treatment strategy. Mitochondrial transfer is emerging as a promising and precisely regulated therapeutic strategy for treating metabolic disorders. This paper specifically reviews the characteristics of mitochondrial energy metabolism across different types of HF and explores the modes and mechanisms of mitochondrial transfer between different cell types in the heart, such as cardiomyocytes, fibroblasts, and immune cells. We focused on the therapeutic potential of intercellular mitochondrial transfer in improving energy metabolism disorders in HF. We also discuss the role of signal transduction in mitochondrial transfer, highlighting that mitochondria not only function as energy factories but also play crucial roles in intercellular communication, metabolic regulation, and tissue repair. This study provides new insights into improving energy metabolism in heart failure patients and proposes promising new therapeutic strategies. |
| format | Article |
| id | doaj-art-72babd877a7e49bfb71795866012e7e8 |
| institution | Kabale University |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-72babd877a7e49bfb71795866012e7e82025-01-09T06:13:05ZengElsevierPharmacological Research1096-11862025-01-01211107555Intercellular Mitochondrial transfer: Therapeutic implications for energy metabolism in heart failureHuan He0Weiwei Huang1Zigang Pan2Lingjun Wang3Zhongqi Yang4Zixin Chen5State Key Laboratory of Traditional Chinese Medicine Syndrome, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, PR ChinaState Key Laboratory of Traditional Chinese Medicine Syndrome, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, PR ChinaState Key Laboratory of Traditional Chinese Medicine Syndrome, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, PR ChinaState Key Laboratory of Traditional Chinese Medicine Syndrome, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China; Guangzhou Key Laboratory of Chinese Medicine for Prevention and Treatment of Chronic Heart Failure, Guangzhou 510405, PR ChinaState Key Laboratory of Traditional Chinese Medicine Syndrome, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China; Guangzhou Key Laboratory of Chinese Medicine for Prevention and Treatment of Chronic Heart Failure, Guangzhou 510405, PR China; Correspondence to: State Key Laboratory of Traditional Chinese Medicine Syndrome, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, No. 16 Airport Road Baiyun District, Guangzhou 510405 PR China.State Key Laboratory of Traditional Chinese Medicine Syndrome, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China; Guangzhou Key Laboratory of Chinese Medicine for Prevention and Treatment of Chronic Heart Failure, Guangzhou 510405, PR China; Correspondence to: State Key Laboratory of Traditional Chinese Medicine Syndrome, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, No. 16 Airport Road Baiyun District, Guangzhou 510405 PR China.Heart failure (HF) remains one of the leading causes of high morbidity and mortality globally. Impaired cardiac energy metabolism plays a critical role in the pathological progression of HF. Various forms of HF exhibit marked differences in energy metabolism, particularly in mitochondrial function and substrate utilization. Recent studies have increasingly highlighted that improving energy metabolism in HF patients as a crucial treatment strategy. Mitochondrial transfer is emerging as a promising and precisely regulated therapeutic strategy for treating metabolic disorders. This paper specifically reviews the characteristics of mitochondrial energy metabolism across different types of HF and explores the modes and mechanisms of mitochondrial transfer between different cell types in the heart, such as cardiomyocytes, fibroblasts, and immune cells. We focused on the therapeutic potential of intercellular mitochondrial transfer in improving energy metabolism disorders in HF. We also discuss the role of signal transduction in mitochondrial transfer, highlighting that mitochondria not only function as energy factories but also play crucial roles in intercellular communication, metabolic regulation, and tissue repair. This study provides new insights into improving energy metabolism in heart failure patients and proposes promising new therapeutic strategies.http://www.sciencedirect.com/science/article/pii/S1043661824005000Mitochondrial transferHeart failureEnergy metabolismCardiomyocyte repairRegenerative therapy |
| spellingShingle | Huan He Weiwei Huang Zigang Pan Lingjun Wang Zhongqi Yang Zixin Chen Intercellular Mitochondrial transfer: Therapeutic implications for energy metabolism in heart failure Pharmacological Research Mitochondrial transfer Heart failure Energy metabolism Cardiomyocyte repair Regenerative therapy |
| title | Intercellular Mitochondrial transfer: Therapeutic implications for energy metabolism in heart failure |
| title_full | Intercellular Mitochondrial transfer: Therapeutic implications for energy metabolism in heart failure |
| title_fullStr | Intercellular Mitochondrial transfer: Therapeutic implications for energy metabolism in heart failure |
| title_full_unstemmed | Intercellular Mitochondrial transfer: Therapeutic implications for energy metabolism in heart failure |
| title_short | Intercellular Mitochondrial transfer: Therapeutic implications for energy metabolism in heart failure |
| title_sort | intercellular mitochondrial transfer therapeutic implications for energy metabolism in heart failure |
| topic | Mitochondrial transfer Heart failure Energy metabolism Cardiomyocyte repair Regenerative therapy |
| url | http://www.sciencedirect.com/science/article/pii/S1043661824005000 |
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