Deconvolution of cargo delivery and immunogenicity following intranasal delivery of mRNA lipid nanoparticle vaccines

Deconvolution of cargo delivery and immunogenicity following intranasal delivery of mRNA lipid nanoparticle vaccines

Intranasal vaccination aims to elicit mucosal immunity in the respiratory tract to better protect against respiratory infections (e.g., SARS-CoV-2 and influenza). Most vaccines, including recent COVID-19 mRNA lipid nanoparticles (LNPs), are optimized for intramuscular (i.m.) administration and typic...

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Bibliographic Details
Main Authors: Mai N. Vu, Devaki Pilapitiya, Andrew Kelly, Marios Koutsakos, Stephen J. Kent, Jennifer A. Juno, Hyon-Xhi Tan, Adam K. Wheatley
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Delivery Strategies
mRNA lipid nanoparticle
intranasal vaccination
prime and pull
transfection efficiency
mucosal immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253125001015
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