Structural basis of collagen glucosyltransferase function and its serendipitous role in kojibiose synthesis

Structural basis of collagen glucosyltransferase function and its serendipitous role in kojibiose synthesis

Abstract Collagen glucosyltransferases catalyze collagen glucosylation critical for biology and diseases, yet their structural regulation remains unclear. Here, we report crystal structures of a mimiviral collagen glucosyltransferase in its apo form and in complexes with uridine diphosphate (UDP) an...

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Main Authors: Jeong Seon Kim, Zhenhang Chen, Sara Andrea Espinosa Garcia, Christoph Buhlheller, Botao Zhang, Stephen J. Richards, Tingfei Chen, Jingjing Wu, Ronald C. Bruntz, Marisa E. Gilliam, Mitsuo Yamauchi, Bo Liang, Houfu Guo
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61973-x
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https://doi.org/10.1038/s41467-025-61973-x

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