Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Background. Several studies have reported that statins have anti-inflammatory effects. Nevertheless, results of clinical trials concerning the effect of statins on the levels of C-reactive protein (CRP) and high-sensitivity CRP (hs-CRP) have been inconsistent. Therefore, we performed a systematic re...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2022/8732360 |
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| author | Tahmineh Kandelouei Mitra Abbasifard Danyal Imani Saeed Aslani Bahman Razi Mahdieh Fasihi Sajad Shafiekhani Keyhan Mohammadi Tannaz Jamialahmadi Željko Reiner Amirhossein Sahebkar |
| author_facet | Tahmineh Kandelouei Mitra Abbasifard Danyal Imani Saeed Aslani Bahman Razi Mahdieh Fasihi Sajad Shafiekhani Keyhan Mohammadi Tannaz Jamialahmadi Željko Reiner Amirhossein Sahebkar |
| author_sort | Tahmineh Kandelouei |
| collection | DOAJ |
| description | Background. Several studies have reported that statins have anti-inflammatory effects. Nevertheless, results of clinical trials concerning the effect of statins on the levels of C-reactive protein (CRP) and high-sensitivity CRP (hs-CRP) have been inconsistent. Therefore, we performed a systematic review and meta-analysis of randomized clinical trials (RCTs) evaluating the effect of statins on CRP and hs-CRP levels in patients with cardiovascular diseases (CVDs). Methods. Literature search of the major databases was performed to find eligible RCTs assessing the effect of statins on serum levels of CRP and hs-CRP from the inception until the last week of April 2021. The effect sizes were determined for weighted mean difference (WMD) and 95% confidence intervals (CI). Results. 26 studies were identified (3010 patients and 2968 controls) for hs-CRP and 20 studies (3026 patients and 2968 controls) for CRP. Statins reduced the serum levels of hs-CRP (WMD=−0.97 mg/L; 95% CI: -1.26 to -0.68 mg/L; P<0.001) and CRP (WMD=−3.05 mg/L; 95% CI: -4.86 to -1.25 mg/L; P<0.001) in patients with CVDs. Statins decreased the serum levels of hs-CRP in patients receiving both high-intensity and moderate/low-intensity treatments with these drugs. In addition, the duration of treatment longer than 10 weeks decreased hs-CRP levels. Only high-intensity statin treatment could marginally decrease serum levels of CRP in CVDs patients. Conclusions. This meta-analysis showed the efficacy of statins to reduce the concentrations of CRP and hs-CRP in patients with different types of CVDs. |
| format | Article |
| id | doaj-art-7277f915ff654080a0fc51063c6f6e18 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-7277f915ff654080a0fc51063c6f6e182025-02-03T05:53:07ZengWileyMediators of Inflammation1466-18612022-01-01202210.1155/2022/8732360Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsTahmineh Kandelouei0Mitra Abbasifard1Danyal Imani2Saeed Aslani3Bahman Razi4Mahdieh Fasihi5Sajad Shafiekhani6Keyhan Mohammadi7Tannaz Jamialahmadi8Željko Reiner9Amirhossein Sahebkar10Department of Oncological SciencesMolecular Medicine Research CenterDepartment of ImmunologyDepartment of ImmunologyDepartment of Hematology and Blood TransfusionDepartment of ImmunologyDepartments of Biomedical EngineeringFaculty of PharmacyDepartment of NutritionDepartment of Internal MedicineApplied Biomedical Research CenterBackground. Several studies have reported that statins have anti-inflammatory effects. Nevertheless, results of clinical trials concerning the effect of statins on the levels of C-reactive protein (CRP) and high-sensitivity CRP (hs-CRP) have been inconsistent. Therefore, we performed a systematic review and meta-analysis of randomized clinical trials (RCTs) evaluating the effect of statins on CRP and hs-CRP levels in patients with cardiovascular diseases (CVDs). Methods. Literature search of the major databases was performed to find eligible RCTs assessing the effect of statins on serum levels of CRP and hs-CRP from the inception until the last week of April 2021. The effect sizes were determined for weighted mean difference (WMD) and 95% confidence intervals (CI). Results. 26 studies were identified (3010 patients and 2968 controls) for hs-CRP and 20 studies (3026 patients and 2968 controls) for CRP. Statins reduced the serum levels of hs-CRP (WMD=−0.97 mg/L; 95% CI: -1.26 to -0.68 mg/L; P<0.001) and CRP (WMD=−3.05 mg/L; 95% CI: -4.86 to -1.25 mg/L; P<0.001) in patients with CVDs. Statins decreased the serum levels of hs-CRP in patients receiving both high-intensity and moderate/low-intensity treatments with these drugs. In addition, the duration of treatment longer than 10 weeks decreased hs-CRP levels. Only high-intensity statin treatment could marginally decrease serum levels of CRP in CVDs patients. Conclusions. This meta-analysis showed the efficacy of statins to reduce the concentrations of CRP and hs-CRP in patients with different types of CVDs.http://dx.doi.org/10.1155/2022/8732360 |
| spellingShingle | Tahmineh Kandelouei Mitra Abbasifard Danyal Imani Saeed Aslani Bahman Razi Mahdieh Fasihi Sajad Shafiekhani Keyhan Mohammadi Tannaz Jamialahmadi Željko Reiner Amirhossein Sahebkar Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Mediators of Inflammation |
| title | Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_full | Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_fullStr | Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_full_unstemmed | Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_short | Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_sort | effect of statins on serum level of hs crp and crp in patients with cardiovascular diseases a systematic review and meta analysis of randomized controlled trials |
| url | http://dx.doi.org/10.1155/2022/8732360 |
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