Advances in the application and research of biomaterials in promoting bone repair and regeneration through immune modulation
With the ongoing development of osteoimmunology, increasing evidence indicates that the local immune microenvironment plays a critical role in various stages of bone formation. Consequently, modulating the immune inflammatory response triggered by biomaterials to foster a more favorable immune micro...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S259000642400471X |
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| author | Li Liu Hao Chen Xue Zhao Qing Han Yongjun Xu Yang Liu Aobo Zhang Yongyue Li Weilong Zhang Bingpeng Chen Jincheng Wang |
| author_facet | Li Liu Hao Chen Xue Zhao Qing Han Yongjun Xu Yang Liu Aobo Zhang Yongyue Li Weilong Zhang Bingpeng Chen Jincheng Wang |
| author_sort | Li Liu |
| collection | DOAJ |
| description | With the ongoing development of osteoimmunology, increasing evidence indicates that the local immune microenvironment plays a critical role in various stages of bone formation. Consequently, modulating the immune inflammatory response triggered by biomaterials to foster a more favorable immune microenvironment for bone regeneration has emerged as a novel strategy in bone tissue engineering. This review first examines the roles of various immune cells in bone tissue injury and repair. Then, the contributions of different biomaterials, including metals, bioceramics, and polymers, in promoting osteogenesis through immune regulation, as well as their future development directions, are discussed. Finally, various design strategies, such as modifying the physicochemical properties of biomaterials and integrating bioactive substances, to optimize material design and create an immune environment conducive to bone formation, are explored. In summary, this review comprehensively covers strategies and approaches for promoting bone tissue regeneration through immune modulation. It offers a thorough understanding of current research trends in biomaterial-based immune regulation, serving as a theoretical reference for the further development and clinical application of biomaterials in bone tissue engineering. |
| format | Article |
| id | doaj-art-726de3c942854ac99595bfeab6338204 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-726de3c942854ac99595bfeab63382042025-01-17T04:52:08ZengElsevierMaterials Today Bio2590-00642025-02-0130101410Advances in the application and research of biomaterials in promoting bone repair and regeneration through immune modulationLi Liu0Hao Chen1Xue Zhao2Qing Han3Yongjun Xu4Yang Liu5Aobo Zhang6Yongyue Li7Weilong Zhang8Bingpeng Chen9Jincheng Wang10Department of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun, 130000, Jilin, ChinaDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun, 130000, Jilin, ChinaDepartment of Endocrinology, The First Hospital of Jilin University, Changchun, 130000, Jilin, ChinaDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun, 130000, Jilin, ChinaDepartment of Orthopedics Surgery, Wangqing County People's Hospital, Yanbian, 133000, Jilin, ChinaDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun, 130000, Jilin, ChinaDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun, 130000, Jilin, ChinaDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun, 130000, Jilin, ChinaDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun, 130000, Jilin, ChinaDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun, 130000, Jilin, China; Corresponding author.Department of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun, 130000, Jilin, ChinaWith the ongoing development of osteoimmunology, increasing evidence indicates that the local immune microenvironment plays a critical role in various stages of bone formation. Consequently, modulating the immune inflammatory response triggered by biomaterials to foster a more favorable immune microenvironment for bone regeneration has emerged as a novel strategy in bone tissue engineering. This review first examines the roles of various immune cells in bone tissue injury and repair. Then, the contributions of different biomaterials, including metals, bioceramics, and polymers, in promoting osteogenesis through immune regulation, as well as their future development directions, are discussed. Finally, various design strategies, such as modifying the physicochemical properties of biomaterials and integrating bioactive substances, to optimize material design and create an immune environment conducive to bone formation, are explored. In summary, this review comprehensively covers strategies and approaches for promoting bone tissue regeneration through immune modulation. It offers a thorough understanding of current research trends in biomaterial-based immune regulation, serving as a theoretical reference for the further development and clinical application of biomaterials in bone tissue engineering.http://www.sciencedirect.com/science/article/pii/S259000642400471XBone tissue engineeringImmune cellsBiomaterialOsteogenesisImmunomodulatorySurface modification |
| spellingShingle | Li Liu Hao Chen Xue Zhao Qing Han Yongjun Xu Yang Liu Aobo Zhang Yongyue Li Weilong Zhang Bingpeng Chen Jincheng Wang Advances in the application and research of biomaterials in promoting bone repair and regeneration through immune modulation Materials Today Bio Bone tissue engineering Immune cells Biomaterial Osteogenesis Immunomodulatory Surface modification |
| title | Advances in the application and research of biomaterials in promoting bone repair and regeneration through immune modulation |
| title_full | Advances in the application and research of biomaterials in promoting bone repair and regeneration through immune modulation |
| title_fullStr | Advances in the application and research of biomaterials in promoting bone repair and regeneration through immune modulation |
| title_full_unstemmed | Advances in the application and research of biomaterials in promoting bone repair and regeneration through immune modulation |
| title_short | Advances in the application and research of biomaterials in promoting bone repair and regeneration through immune modulation |
| title_sort | advances in the application and research of biomaterials in promoting bone repair and regeneration through immune modulation |
| topic | Bone tissue engineering Immune cells Biomaterial Osteogenesis Immunomodulatory Surface modification |
| url | http://www.sciencedirect.com/science/article/pii/S259000642400471X |
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