Integrative network pharmacology and experimental validation reveal emodin derivatives as potential therapeutics for hepatocellular carcinoma

Integrative network pharmacology and experimental validation reveal emodin derivatives as potential therapeutics for hepatocellular carcinoma

Abstract Background Hepatocellular carcinoma (HCC) is a major global health concern due to its high prevalence and mortality rate. Although emodin, a natural anthraquinone derivative, has demonstrated in vitro anticancer activity against HCC cells, its specific molecular targets in HCC remain unclea...

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Main Authors: Wirawan Adikusuma, Firdayani Firdayani, Siska Andrina Kusumastuti, Nuralih Nuralih, Shelvi Listiana, Ayu Masyita, Lalu Muhammad Irham, Siti Hodijah, Suci Zulaikha Hildayani, Eko Mugiyanto
Format: Article
Language:English
Published: SpringerOpen 2025-07-01
Series:Journal of the Egyptian National Cancer Institute
Subjects:
Hepatocellular carcinoma
Emodin derivatives
Network pharmacology
Cytotoxicity assay
Molecular docking
Molecular dynamics simulation
Online Access:https://doi.org/10.1186/s43046-025-00306-x
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https://doi.org/10.1186/s43046-025-00306-x

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