Conditionally replicative adenovirus as a therapy for malignant peripheral nerve sheath tumors

Conditionally replicative adenovirus as a therapy for malignant peripheral nerve sheath tumors

Oncolytic adenoviruses (Ads) stand out as a promising strategy for the targeted infection and lysis of tumor cells, with well-established clinical utility across various malignancies. This study delves into the therapeutic potential of oncolytic Ads in the context of neurofibromatosis type 1 (NF1)-a...

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Main Authors: Julia A. Nikrad, Robert T. Galvin, Mackenzie M. Sheehy, Ethan L. Novacek, Kari L. Jacobsen, Stanislas M.A.S. Corbière, Pauline J. Beckmann, Tyler A. Jubenville, Masato Yamamoto, David A. Largaespada
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
neurofibromatosis type 1 (NF1)
oncolytic adenovirus
malignant peripheral nerve sheath tumor (MPNST)
conditionally replicative adenovirus (CRAd)
cyclooxygenase 2 (COX2)
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329924000250
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