SMART: spatial transcriptomics deconvolution using marker-gene-assisted topic model

SMART: spatial transcriptomics deconvolution using marker-gene-assisted topic model

Abstract While spatial transcriptomics offer valuable insights into gene expression patterns within the spatial context of tissue, many technologies do not have a single-cell resolution. Here, we present SMART, a marker gene-assisted deconvolution method that simultaneously infers the cell type-spec...

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Bibliographic Details
Main Authors: Chen Xi Yang, Don D. Sin, Raymond T. Ng
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Genome Biology
Subjects:
Spatial transcriptomics
Deconvolution
Semi-supervised
Topic models
Online Access:https://doi.org/10.1186/s13059-024-03441-1
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https://doi.org/10.1186/s13059-024-03441-1

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