The promise and challenges of pharmacogenomics in psychiatry
Pharmacogenomics (PGx) is an expanding field within precision medicine that is poised to play a crucial role in optimising patient outcomes, particularly in the realm of psychiatry. The remission rate for the initial antidepressant prescribed in the Sequenced Treatment Alternatives to Relieve Depre...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Academy of Medicine Singapore
2024-12-01
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| Series: | Annals, Academy of Medicine, Singapore |
| Online Access: | https://annals.edu.sg/the-promise-and-challenges-of-pharmacogenomics-in-psychiatry/ |
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| Summary: | Pharmacogenomics (PGx) is an expanding field within precision medicine that is poised to play a crucial role in optimising patient outcomes, particularly in the realm of psychiatry. The remission rate for the initial antidepressant prescribed in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial was only approximately 30%, underscoring the need for more personalised approaches to prescribing.1 For psychiatric patients who may show resistance towards pharmacotherapy, PGx offers promise in reducing adverse effects and enhancing therapeutic efficacy. Personalised pharmacotherapy provides reassurance and potentially mitigates the nocebo effects and somatic symptom exacerbation that are prevalent among these patients. |
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| ISSN: | 2972-4066 |