Smooth muscle-specific expression of hydroxyindole O-methyltransferase reduces arterial injury-induced intimal hyperplasia

Smooth muscle-specific expression of hydroxyindole O-methyltransferase reduces arterial injury-induced intimal hyperplasia

Abstract Background The pineal gland produces melatonin to control circadian rhythm via the final enzyme in the serotonin pathway, hydroxyindole O-methyltransferase (HIOMT). Interestingly, HIOMT is expressed by certain non-pineal cells. The main catalytically active of the three human HIOMT (hHIOMT)...

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Main Authors: Wei-Cheng Jiang, Chung-Huang Chen, Hua-Hui Ho, Pei-Yu Gung, Jing-Yiing Wu, Cheng-Chin Kuo, Kenneth K. Wu, Shaw-Fang Yet
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Biomedical Science
Subjects:
Hydroxyindole O-methyltransferase
5-Methoxytryptophan
Serotonin
Intimal hyperplasia
Vascular smooth muscle cells
Online Access:https://doi.org/10.1186/s12929-025-01172-4
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https://doi.org/10.1186/s12929-025-01172-4

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