Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria

Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria

Abstract The caseinolytic protease complex ClpP1P2 is crucial for protein homeostasis in mycobacteria and stress response and virulence of the pathogens. Its role as a potential drug target for combating tuberculosis (TB) has just begun to be substantiated in drug discovery research. We conducted a...

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Bibliographic Details
Main Authors: Genhui Xiao, Yumeng Cui, Liangliang Zhou, Chuya Niu, Bing Wang, Jinglan Wang, Shaoyang Zhou, Miaomiao Pan, Chi Kin Chan, Yan Xia, Lan Xu, Yu Lu, Shawn Chen
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:mLife
Subjects:
caseinolytic protease
chemical–genetic interaction
drug combination
enzyme inhibitor
mycobacteria
Online Access:https://doi.org/10.1002/mlf2.12169
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https://doi.org/10.1002/mlf2.12169

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