Altered immune signatures in breast cancer lymph nodes with metastases revealed by spatial proteome analyses

Abstract Background Metastasis to lymph nodes is strongly associated with reduced survival in breast cancer patients. To increase the understanding on how lymph node metastasis impairs the local immune response in affected lymph nodes, we here studied spatial proteomic changes of critical lymph node...

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Main Authors: Oscar Briem, Balázs Tahin, Asger Meldgaard Frank, Lina Olsson, Anna Sandström Gerdtsson, Eva Källberg, Karin Leandersson
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Translational Medicine
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Online Access:https://doi.org/10.1186/s12967-025-06415-4
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