Ruxolitinib and pegylated interferon in Chronic Neutrophilic Leukemia due to a pathogenic CSF3R germline variant: a case report

Ruxolitinib and pegylated interferon in Chronic Neutrophilic Leukemia due to a pathogenic CSF3R germline variant: a case report

Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm characterized by CSF3R mutations. Here, we report the first case of a CNL patient positive for a de-novo germline CSF3R T618I variant effectively treated with ruxolitinib and pegylated interferon (peg-IFN), obtaining normaliza...

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Bibliographic Details
Main Authors: Selene Grano, Valentina Bonuomo, Diana Carli, Veronica Peri, Loredana Farinasso, Ugo Ramenghi, Daniela Cilloni, Carmen Fava
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Hematology
Subjects:
case report
chronic neutrophilic leukemia
myeloproliferative neoplasm
CSF3R mutation
NGS
Online Access:https://www.frontiersin.org/articles/10.3389/frhem.2024.1508463/full
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https://www.frontiersin.org/articles/10.3389/frhem.2024.1508463/full

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