Identifying kinematic biomarkers of the dystrophic phenotype in a zebrafish model of Duchenne muscular dystrophy

Identifying kinematic biomarkers of the dystrophic phenotype in a zebrafish model of Duchenne muscular dystrophy

Abstract Background Dystrophin-deficient zebrafish larvae are a small, genetically tractable vertebrate model of Duchenne muscular dystrophy that is well suited for early-stage therapeutic development. However, current approaches for evaluating their mobility, a physiologically relevant therapeutic...

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Main Authors: Jeffrey J. Widrick, Matthias R. Lambert, Felipe de Souza Leite, Youngsook Lucy Jung, Junseok Park, James R. Conner, Eunjung Alice Lee, Alan H. Beggs, Louis M. Kunkel
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Skeletal Muscle
Subjects:
Duchenne muscular dystrophy
Kinematics
Swimming
Mobility
DeepLabCut
Markerless motion capture
Online Access:https://doi.org/10.1186/s13395-025-00382-6
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https://doi.org/10.1186/s13395-025-00382-6

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