Case report: Advanced age at transplantation and pre-emptive treatment with dupilumab in DOCK8 deficiency

Case report: Advanced age at transplantation and pre-emptive treatment with dupilumab in DOCK8 deficiency

Dedicator of cytokinesis 8 (DOCK8) deficiency is a combined immunodeficiency (CID) due to biallelic mutations in the gene encoding DOCK8. Major clinical phenomena are recurrent severe infections of the lungs and skin, atopic eczema, and predisposition to malignancy leading to a poor prognosis. Typic...

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Bibliographic Details
Main Authors: Sophia Trombello, Andrea Jarisch, Andre Willasch, Eva Rettinger, Julia Fekadu-Siebald, Dirk Holzinger, Roland Adelmann, Peter Bader, Shahrzad Bakhtiar
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
DOCK8-deficiency
alloHSCT
dupilumab
combined immunodeficiency
omalizumab
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1507494/full
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