Loss of C-Terminal Coiled-Coil Domains in SDCCAG8 Impairs Centriolar Satellites and Causes Defective Sperm Flagellum Biogenesis and Male Fertility

Loss of C-Terminal Coiled-Coil Domains in SDCCAG8 Impairs Centriolar Satellites and Causes Defective Sperm Flagellum Biogenesis and Male Fertility

Sperm flagellum defects are tightly associated with male infertility. Centriolar satellites are small multiprotein complexes that recruit satellite proteins to the centrosome and play an essential role in sperm flagellum biogenesis, but the precise mechanisms underlying this role remain unclear. <...

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Bibliographic Details
Main Authors: Kecheng Li, Xiaoli Zhou, Wenna Liu, Yange Wang, Zilong Zhang, Houbin Zhang, Li Jiang
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
SDCCAG8
centriolar satellites
male infertility
sperm flagellum biogenesis
MMAF
spermiogenesis
Online Access:https://www.mdpi.com/2073-4409/14/15/1135
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https://www.mdpi.com/2073-4409/14/15/1135

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