Resolving mechanisms of immune‐mediated disease in primary CD4 T cells

Resolving mechanisms of immune‐mediated disease in primary CD4 T cells

Abstract Deriving mechanisms of immune‐mediated disease from GWAS data remains a formidable challenge, with attempts to identify causal variants being frequently hampered by strong linkage disequilibrium. To determine whether causal variants could be identified from their functional effects, we adap...

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Main Authors: Christophe Bourges, Abigail F Groff, Oliver S Burren, Chiara Gerhardinger, Kaia Mattioli, Anna Hutchinson, Theodore Hu, Tanmay Anand, Madeline W Epping, Chris Wallace, Kenneth GC Smith, John L Rinn, James C Lee
Format: Article
Language:English
Published: Springer Nature 2020-04-01
Series:EMBO Molecular Medicine
Subjects:
CD4 T cells
GWAS
MPRA
super‐enhancer
TNFAIP3
Online Access:https://doi.org/10.15252/emmm.202012112
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https://doi.org/10.15252/emmm.202012112

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