A wheat germ-rich diet preserves bone homeostasis by regulating gut microbiota and plasma metabolites in aged rats
Bone loss caused by ageing has become one of the leading health risk factors worldwide. Wheat germ (WG) is consists of high amounts of bioactive peptides, polyunsaturated fatty acids, and dietary fibre. Currently, WG has been proven to possess strong antioxidant and anti-inflammatory properties. We...
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Tsinghua University Press
2024-11-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2023.9250040 |
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| author | Luanfeng Wang Zebin Weng Tong Chen Yu Li Ling Xiong Haizhao Song Fang Wang Xiaozhi Tang Bo Ren Xuebo Liu Xinchun Shen |
| author_facet | Luanfeng Wang Zebin Weng Tong Chen Yu Li Ling Xiong Haizhao Song Fang Wang Xiaozhi Tang Bo Ren Xuebo Liu Xinchun Shen |
| author_sort | Luanfeng Wang |
| collection | DOAJ |
| description | Bone loss caused by ageing has become one of the leading health risk factors worldwide. Wheat germ (WG) is consists of high amounts of bioactive peptides, polyunsaturated fatty acids, and dietary fibre. Currently, WG has been proven to possess strong antioxidant and anti-inflammatory properties. We recently explored the beneficial effects and relevant mechanisms of a WG-rich diet (2.5% and 5% WG, m/m) on bone homeostasis in aged rats. Our results showed that 5% WG supplementation for 12 months effectively attenuated ageing-induced microstructural damage and differentiation activity changes in the femur. The 5% WG supplementation also significantly increased the levels of total antioxidant capacity (T-AOC), glutathione peroxidase (GSH-Px) (P < 0.01), and superoxide dismutase (SOD) (P < 0.05), and decreased inflammatory cytokine levels (tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6)) (P < 0.01). Furthermore, the WG-rich diet reshaped the composition of the gut microbiota, enhancing short-chain fatty acids (SCFAs)-producing microbes and reducing inflammation-related microbes. In addition, metabolomics analysis showed that 5% WG supplementation improved plasma metabolites related to bone metabolism. Conclusively, our study purports long-term WG-rich diet may preserve bone homeostasis by regulating gut microbiota and plasma metabolites in aged rats. |
| format | Article |
| id | doaj-art-6f3dc6b7a8c14ce0afa693ee8e9ff922 |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-6f3dc6b7a8c14ce0afa693ee8e9ff9222025-01-10T06:57:02ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-11-011363582359410.26599/FSHW.2023.9250040A wheat germ-rich diet preserves bone homeostasis by regulating gut microbiota and plasma metabolites in aged ratsLuanfeng Wang0Zebin Weng1Tong Chen2Yu Li3Ling Xiong4Haizhao Song5Fang Wang6Xiaozhi Tang7Bo Ren8Xuebo Liu9Xinchun Shen10College of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, ChinaSchool of Traditional Chinese Medicine & School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaCollege of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, ChinaCollege of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, ChinaCollege of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, ChinaCollege of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, ChinaCollege of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, ChinaCollege of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, ChinaSchool of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, ChinaCollege of Food Science and Engineering, Northwest A&F University, Yangling 712100, ChinaCollege of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, ChinaBone loss caused by ageing has become one of the leading health risk factors worldwide. Wheat germ (WG) is consists of high amounts of bioactive peptides, polyunsaturated fatty acids, and dietary fibre. Currently, WG has been proven to possess strong antioxidant and anti-inflammatory properties. We recently explored the beneficial effects and relevant mechanisms of a WG-rich diet (2.5% and 5% WG, m/m) on bone homeostasis in aged rats. Our results showed that 5% WG supplementation for 12 months effectively attenuated ageing-induced microstructural damage and differentiation activity changes in the femur. The 5% WG supplementation also significantly increased the levels of total antioxidant capacity (T-AOC), glutathione peroxidase (GSH-Px) (P < 0.01), and superoxide dismutase (SOD) (P < 0.05), and decreased inflammatory cytokine levels (tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6)) (P < 0.01). Furthermore, the WG-rich diet reshaped the composition of the gut microbiota, enhancing short-chain fatty acids (SCFAs)-producing microbes and reducing inflammation-related microbes. In addition, metabolomics analysis showed that 5% WG supplementation improved plasma metabolites related to bone metabolism. Conclusively, our study purports long-term WG-rich diet may preserve bone homeostasis by regulating gut microbiota and plasma metabolites in aged rats.https://www.sciopen.com/article/10.26599/FSHW.2023.9250040wheat germbone homeostasisgut microbiotametabolitesageing |
| spellingShingle | Luanfeng Wang Zebin Weng Tong Chen Yu Li Ling Xiong Haizhao Song Fang Wang Xiaozhi Tang Bo Ren Xuebo Liu Xinchun Shen A wheat germ-rich diet preserves bone homeostasis by regulating gut microbiota and plasma metabolites in aged rats Food Science and Human Wellness wheat germ bone homeostasis gut microbiota metabolites ageing |
| title | A wheat germ-rich diet preserves bone homeostasis by regulating gut microbiota and plasma metabolites in aged rats |
| title_full | A wheat germ-rich diet preserves bone homeostasis by regulating gut microbiota and plasma metabolites in aged rats |
| title_fullStr | A wheat germ-rich diet preserves bone homeostasis by regulating gut microbiota and plasma metabolites in aged rats |
| title_full_unstemmed | A wheat germ-rich diet preserves bone homeostasis by regulating gut microbiota and plasma metabolites in aged rats |
| title_short | A wheat germ-rich diet preserves bone homeostasis by regulating gut microbiota and plasma metabolites in aged rats |
| title_sort | wheat germ rich diet preserves bone homeostasis by regulating gut microbiota and plasma metabolites in aged rats |
| topic | wheat germ bone homeostasis gut microbiota metabolites ageing |
| url | https://www.sciopen.com/article/10.26599/FSHW.2023.9250040 |
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