Molecular spectroscopy of blood plasma differentiates metabolic dysfunction-associated steatohepatitis from steatosis

Molecular spectroscopy of blood plasma differentiates metabolic dysfunction-associated steatohepatitis from steatosis

Abstract Background Vibrational and chiroptical spectroscopy of blood plasma is an advanced experimental diagnostic approach that allows the identification of disease-specific molecular patterns. This study aimed to test its potential to distinguish between different stages of metabolic dysfunction-...

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Main Authors: Barbora Nováková, Ondřej Vrtělka, Kateřina Králová, Lucie Habartová, Václav Šmíd, Karel Dvořák, Jaromír Petrtýl, Kateřina Žížalová, Jan Stříteský, Libor Vítek, Martin Leníček, Vladimír Setnička, Radan Brůha
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
Metabolic dysfunction-associated steatohepatitis (MASH)
Metabolic dysfunction-associated steatotic liver disease (MASLD)
Liver fibrosis
Simple steatosis
Fourier-transform infrared (FTIR) spectroscopy
Raman spectroscopy
Online Access:https://doi.org/10.1186/s12967-025-06885-6
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https://doi.org/10.1186/s12967-025-06885-6

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