Impact of obesity on iron metabolism and the effect of intravenous iron supplementation in obese patients with absolute iron deficiency
Abstract Obesity and iron deficiency (ID) are widespread health issues, with subclinical inflammation in obesity potentially contributing to ID through unclear mechanisms. The aim of the present work was to elucidate how obesity-associated inflammation disturb iron metabolism and to investigate the...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-84498-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841544821312847872 |
|---|---|
| author | Laura Tarancon-Diez Marianela Iriarte-Gahete Pilar Sanchez-Mingo Mª Ángeles Muñoz-Fernandez Maria Luisa Navarro-Gomez Yolanda M. Pacheco Manuel Leal |
| author_facet | Laura Tarancon-Diez Marianela Iriarte-Gahete Pilar Sanchez-Mingo Mª Ángeles Muñoz-Fernandez Maria Luisa Navarro-Gomez Yolanda M. Pacheco Manuel Leal |
| author_sort | Laura Tarancon-Diez |
| collection | DOAJ |
| description | Abstract Obesity and iron deficiency (ID) are widespread health issues, with subclinical inflammation in obesity potentially contributing to ID through unclear mechanisms. The aim of the present work was to elucidate how obesity-associated inflammation disturb iron metabolism and to investigate the effect of intravenous (IV) iron supplementation on absolute iron deficient pre-obese (BMI 25.0–29.9 kg/m2) and obese (BMI > 30 kg/m2) individuals compared to healthy weight (HW) group (BMI 18.5–24.9 kg/m2). Iron-related, hematological and inflammatory biomarkers along with erythropoietin (EPO) were studied based on body mass index (BMI) in a Spanish cohort of non-anemic participants (n = 721; 67% women; median age of 48 years [IQR: 39–57]) and in a subgroup of subjects (n = 110) with absolute ID (ferritin < 50 ng/mL) after completing an IV iron therapy. Obese group exhibited higher levels of ferritin, hemoglobin (Hb), soluble transferrin receptor (sTfR) and hepcidin compared to HW group. Elevated BMI was independently associated with increased sTfR levels. While no statistical differences were found in EPO among groups, obese showed increased levels that inversely correlated with Hb only in pre-obese and obese groups. IV iron therapy on obese participants had significant improvements on iron-related parameters and Hb levels. Notable obesity-associated disturbances in iron metabolism are described and indicate a mixed ID among both, women and men. These findings highlight the importance of tailored interventions to correctly address ID in obese population. |
| format | Article |
| id | doaj-art-6f0e28a4d90444f999721b0c3bb5b50b |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-6f0e28a4d90444f999721b0c3bb5b50b2025-01-12T12:16:51ZengNature PortfolioScientific Reports2045-23222025-01-0115111210.1038/s41598-024-84498-7Impact of obesity on iron metabolism and the effect of intravenous iron supplementation in obese patients with absolute iron deficiencyLaura Tarancon-Diez0Marianela Iriarte-Gahete1Pilar Sanchez-Mingo2Mª Ángeles Muñoz-Fernandez3Maria Luisa Navarro-Gomez4Yolanda M. Pacheco5Manuel Leal6Grupo de Infecciones en la Población Pediátrica, Health Research Institute Gregorio Marañón (IiSGM)Immunology Service, Unit of Clinical Laboratories, Institute of Biomedicine of Seville, IBiS / Virgen del Rocío University Hospital / CSIC / University of SevilleSynlab Global Diagnosis, Hospital Viamed Santa Ángela de La CruzMolecular Immunology Laboratory, Hospital General Universitario Gregorio Marañón, Health Research Institute Gregorio Marañón (IiSGM)Grupo de Infecciones en la Población Pediátrica, Health Research Institute Gregorio Marañón (IiSGM)Immunology Service, Unit of Clinical Laboratories, Institute of Biomedicine of Seville, IBiS / Virgen del Rocío University Hospital / CSIC / University of SevilleInternal Medicine Service, Hospital Viamed Santa Ángela de la CruzAbstract Obesity and iron deficiency (ID) are widespread health issues, with subclinical inflammation in obesity potentially contributing to ID through unclear mechanisms. The aim of the present work was to elucidate how obesity-associated inflammation disturb iron metabolism and to investigate the effect of intravenous (IV) iron supplementation on absolute iron deficient pre-obese (BMI 25.0–29.9 kg/m2) and obese (BMI > 30 kg/m2) individuals compared to healthy weight (HW) group (BMI 18.5–24.9 kg/m2). Iron-related, hematological and inflammatory biomarkers along with erythropoietin (EPO) were studied based on body mass index (BMI) in a Spanish cohort of non-anemic participants (n = 721; 67% women; median age of 48 years [IQR: 39–57]) and in a subgroup of subjects (n = 110) with absolute ID (ferritin < 50 ng/mL) after completing an IV iron therapy. Obese group exhibited higher levels of ferritin, hemoglobin (Hb), soluble transferrin receptor (sTfR) and hepcidin compared to HW group. Elevated BMI was independently associated with increased sTfR levels. While no statistical differences were found in EPO among groups, obese showed increased levels that inversely correlated with Hb only in pre-obese and obese groups. IV iron therapy on obese participants had significant improvements on iron-related parameters and Hb levels. Notable obesity-associated disturbances in iron metabolism are described and indicate a mixed ID among both, women and men. These findings highlight the importance of tailored interventions to correctly address ID in obese population.https://doi.org/10.1038/s41598-024-84498-7ObesityIron metabolismIron deficiencyHemoglobinInflammation |
| spellingShingle | Laura Tarancon-Diez Marianela Iriarte-Gahete Pilar Sanchez-Mingo Mª Ángeles Muñoz-Fernandez Maria Luisa Navarro-Gomez Yolanda M. Pacheco Manuel Leal Impact of obesity on iron metabolism and the effect of intravenous iron supplementation in obese patients with absolute iron deficiency Scientific Reports Obesity Iron metabolism Iron deficiency Hemoglobin Inflammation |
| title | Impact of obesity on iron metabolism and the effect of intravenous iron supplementation in obese patients with absolute iron deficiency |
| title_full | Impact of obesity on iron metabolism and the effect of intravenous iron supplementation in obese patients with absolute iron deficiency |
| title_fullStr | Impact of obesity on iron metabolism and the effect of intravenous iron supplementation in obese patients with absolute iron deficiency |
| title_full_unstemmed | Impact of obesity on iron metabolism and the effect of intravenous iron supplementation in obese patients with absolute iron deficiency |
| title_short | Impact of obesity on iron metabolism and the effect of intravenous iron supplementation in obese patients with absolute iron deficiency |
| title_sort | impact of obesity on iron metabolism and the effect of intravenous iron supplementation in obese patients with absolute iron deficiency |
| topic | Obesity Iron metabolism Iron deficiency Hemoglobin Inflammation |
| url | https://doi.org/10.1038/s41598-024-84498-7 |
| work_keys_str_mv | AT lauratarancondiez impactofobesityonironmetabolismandtheeffectofintravenousironsupplementationinobesepatientswithabsoluteirondeficiency AT marianelairiartegahete impactofobesityonironmetabolismandtheeffectofintravenousironsupplementationinobesepatientswithabsoluteirondeficiency AT pilarsanchezmingo impactofobesityonironmetabolismandtheeffectofintravenousironsupplementationinobesepatientswithabsoluteirondeficiency AT maangelesmunozfernandez impactofobesityonironmetabolismandtheeffectofintravenousironsupplementationinobesepatientswithabsoluteirondeficiency AT marialuisanavarrogomez impactofobesityonironmetabolismandtheeffectofintravenousironsupplementationinobesepatientswithabsoluteirondeficiency AT yolandampacheco impactofobesityonironmetabolismandtheeffectofintravenousironsupplementationinobesepatientswithabsoluteirondeficiency AT manuelleal impactofobesityonironmetabolismandtheeffectofintravenousironsupplementationinobesepatientswithabsoluteirondeficiency |