Aspirin modulates inflammatory biomarkers in patients with subcortical silent brain infarcts
IntroductionThis study aimed to identify differences in the levels of inflammation-related biomarkers between patients with subcortical silent brain infarcts (SBIs) and healthy controls. We also evaluated the effect of aspirin on the subcortical SBI inflammatory processes.MethodsConsecutive patients...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1507683/full |
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| author | Wonjae Sung Young Seo Kim Kyu-Yong Lee Jae-A Jung Hojin Choi Young Joo Lee Seong-Ho Koh Seong-Ho Koh |
| author_facet | Wonjae Sung Young Seo Kim Kyu-Yong Lee Jae-A Jung Hojin Choi Young Joo Lee Seong-Ho Koh Seong-Ho Koh |
| author_sort | Wonjae Sung |
| collection | DOAJ |
| description | IntroductionThis study aimed to identify differences in the levels of inflammation-related biomarkers between patients with subcortical silent brain infarcts (SBIs) and healthy controls. We also evaluated the effect of aspirin on the subcortical SBI inflammatory processes.MethodsConsecutive patients diagnosed with subcortical SBIs without a history of acute stroke were included. The demographic and clinical data of the 26 subjects with subcortical SBIs, such as the number and location of subcortical SBIs, were reviewed. Plasma levels of macrophage migration inhibitory factor (MIF), matrix metalloproteinase-9 (MMP-9), and visfatin were measured in patients with subcortical SBIs and ten healthy participants. These biomarkers were rechecked in patients with subcortical SBI 3 months after taking aspirin (100 mg/day).ResultsMIF and MMP-9 levels were significantly higher in patients with subcortical SBIs than in healthy control group (p = 0.031 and p = 0.026, respectively). Although MIF and MMP-9 did not show significant changes after taking aspirin for 3 months, the median plasma level of visfatin was significantly decreased from 1.00 ng/mL (range, 0.86–1.16 ng/mL) to 0.84 ng/mL (range, 0.77–0.91 ng/mL) (p = 0.002) after taking aspirin.DiscussionInflammation could be an essential factor in the pathogenesis of subcortical SBIs, and aspirin affects several inflammation-related biomarkers. |
| format | Article |
| id | doaj-art-6e6a6fc9044c462e86b4af6d3e9886a0 |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-6e6a6fc9044c462e86b4af6d3e9886a02025-01-07T06:40:51ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-01-011610.3389/fnagi.2024.15076831507683Aspirin modulates inflammatory biomarkers in patients with subcortical silent brain infarctsWonjae Sung0Young Seo Kim1Kyu-Yong Lee2Jae-A Jung3Hojin Choi4Young Joo Lee5Seong-Ho Koh6Seong-Ho Koh7Department of Neurology, College of Medicine, Hanyang University Seoul Hospital, Seoul, Republic of KoreaDepartment of Neurology, College of Medicine, Hanyang University Seoul Hospital, Seoul, Republic of KoreaDepartment of Neurology, College of Medicine, Hanyang University Guri Hospital, Guri, Republic of KoreaDepartment of Plastic and Reconstructive Surgery, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Republic of KoreaDepartment of Neurology, College of Medicine, Hanyang University Guri Hospital, Guri, Republic of KoreaDepartment of Neurology, College of Medicine, Hanyang University Guri Hospital, Guri, Republic of KoreaDepartment of Neurology, College of Medicine, Hanyang University Guri Hospital, Guri, Republic of KoreaDepartment of Translational Medicine, Graduate School of Biomedical Science & Engineering, Hanyang University, Seoul, Republic of KoreaIntroductionThis study aimed to identify differences in the levels of inflammation-related biomarkers between patients with subcortical silent brain infarcts (SBIs) and healthy controls. We also evaluated the effect of aspirin on the subcortical SBI inflammatory processes.MethodsConsecutive patients diagnosed with subcortical SBIs without a history of acute stroke were included. The demographic and clinical data of the 26 subjects with subcortical SBIs, such as the number and location of subcortical SBIs, were reviewed. Plasma levels of macrophage migration inhibitory factor (MIF), matrix metalloproteinase-9 (MMP-9), and visfatin were measured in patients with subcortical SBIs and ten healthy participants. These biomarkers were rechecked in patients with subcortical SBI 3 months after taking aspirin (100 mg/day).ResultsMIF and MMP-9 levels were significantly higher in patients with subcortical SBIs than in healthy control group (p = 0.031 and p = 0.026, respectively). Although MIF and MMP-9 did not show significant changes after taking aspirin for 3 months, the median plasma level of visfatin was significantly decreased from 1.00 ng/mL (range, 0.86–1.16 ng/mL) to 0.84 ng/mL (range, 0.77–0.91 ng/mL) (p = 0.002) after taking aspirin.DiscussionInflammation could be an essential factor in the pathogenesis of subcortical SBIs, and aspirin affects several inflammation-related biomarkers.https://www.frontiersin.org/articles/10.3389/fnagi.2024.1507683/fullsubcortical silent brain infarctaspirininflammationmacrophage migration inhibitory factormatrix metalloproteinase-9visfatin |
| spellingShingle | Wonjae Sung Young Seo Kim Kyu-Yong Lee Jae-A Jung Hojin Choi Young Joo Lee Seong-Ho Koh Seong-Ho Koh Aspirin modulates inflammatory biomarkers in patients with subcortical silent brain infarcts Frontiers in Aging Neuroscience subcortical silent brain infarct aspirin inflammation macrophage migration inhibitory factor matrix metalloproteinase-9 visfatin |
| title | Aspirin modulates inflammatory biomarkers in patients with subcortical silent brain infarcts |
| title_full | Aspirin modulates inflammatory biomarkers in patients with subcortical silent brain infarcts |
| title_fullStr | Aspirin modulates inflammatory biomarkers in patients with subcortical silent brain infarcts |
| title_full_unstemmed | Aspirin modulates inflammatory biomarkers in patients with subcortical silent brain infarcts |
| title_short | Aspirin modulates inflammatory biomarkers in patients with subcortical silent brain infarcts |
| title_sort | aspirin modulates inflammatory biomarkers in patients with subcortical silent brain infarcts |
| topic | subcortical silent brain infarct aspirin inflammation macrophage migration inhibitory factor matrix metalloproteinase-9 visfatin |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1507683/full |
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