Cerebrovascular p16INK4A expression induces cerebral small vessel disease-related phenotypes

Cerebrovascular p16INK4A expression induces cerebral small vessel disease-related phenotypes

Abstract Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive impairment and dementia (VCID) and highly associated with Alzheimer’s disease pathogenesis. There is an urgent need to establish relevant animal models for cSVD. As aging is the strongest risk factor for the...

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Main Authors: Keiji Kawatani, Tomonori Aikawa, Zeynab Tabrizi, Yining Pan, Yingxue Ren, Ni Wang, Aishe Kurti, Toshihiko Nambara, Clark C. Ikezu, Francis Shue, Michael Bamkole, Yasuteru Inoue, Tammee M. Parsons, Guojun Bu, Qianqian Song, Oliver Bracko, Takahisa Kanekiyo
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Acta Neuropathologica Communications
Subjects:
AAV
Cerebral small vessel disease
Mouse
p16INK4A
Senescence
VCID
Online Access:https://doi.org/10.1186/s40478-025-02085-x
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https://doi.org/10.1186/s40478-025-02085-x

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