Disrupting TSLP–TSLP receptor interactions via putative small molecule inhibitors yields a novel and efficient treatment option for atopic diseases

Disrupting TSLP–TSLP receptor interactions via putative small molecule inhibitors yields a novel and efficient treatment option for atopic diseases

Abstract Thymic stromal lymphopoietin (TSLP) is a key player in atopic diseases, which has sparked great interest in therapeutically targeting TSLP. Yet, no small-molecule TSLP inhibitors exist due to the challenges of disrupting the protein–protein interaction between TSLP and its receptor. Here, w...

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Main Authors: Partho Protim Adhikary, Temilolu Idowu, Zheng Tan, Christopher Hoang, Selina Shanta, Malti Dumbani, Leah Mappalakayil, Bhuwan Awasthi, Marcel Bermudez, January Weiner, Dieter Beule, Gerhard Wolber, Brent DG Page, Sarah Hedtrich
Format: Article
Language:English
Published: Springer Nature 2024-06-01
Series:EMBO Molecular Medicine
Subjects:
TSLP
Atopic Diseases
Atopic Dermatitis
Organ-on-chip
Small Molecule Inhibitor
Online Access:https://doi.org/10.1038/s44321-024-00085-3
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https://doi.org/10.1038/s44321-024-00085-3

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