Carnosic acid enhances cisplatin sensitivity and suppresses gastric cancer progression via the TP53/SLC7A11/ALOX12 axis

Carnosic acid enhances cisplatin sensitivity and suppresses gastric cancer progression via the TP53/SLC7A11/ALOX12 axis

Abstract Background Gastric cancer (GC) remains a significant global health challenge due to its high mortality and frequent resistance to chemotherapy drugs like cisplatin (DDP). Carnosic acid (CA), a phenolic diterpene, exhibits potential anti-cancer properties. This study aimed to investigate the...

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Bibliographic Details
Main Authors: Li Zhou, Bin Xu, Baojian Li
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Hereditas
Subjects:
Carnosic acid
Gastric cancer
Cisplatin
TP53
Online Access:https://doi.org/10.1186/s41065-025-00508-2
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https://doi.org/10.1186/s41065-025-00508-2

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