Directional microwave ablation in spine: experimental assessment of computational modeling
Background Despite the theoretical advantages of treating metastatic bone disease with microwave ablation (MWA), there are few reports characterizing microwave absorption and bioheat transfer in bone. This report describes a computational modeling-based approach to simulate directional microwave abl...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2313492 |
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| author | Austin Pfannenstiel Haileigh Avellar Clay Hallman Brandon L. Plattner Margaret A. Highland Francois H. Cornelis Warren L. Beard Punit Prakash |
| author_facet | Austin Pfannenstiel Haileigh Avellar Clay Hallman Brandon L. Plattner Margaret A. Highland Francois H. Cornelis Warren L. Beard Punit Prakash |
| author_sort | Austin Pfannenstiel |
| collection | DOAJ |
| description | Background Despite the theoretical advantages of treating metastatic bone disease with microwave ablation (MWA), there are few reports characterizing microwave absorption and bioheat transfer in bone. This report describes a computational modeling-based approach to simulate directional microwave ablation (dMWA) in spine, supported by ex vivo and pilot in vivo experiments in porcine vertebral bodies.Materials and methods A 3D computational model of microwave ablation within porcine vertebral bodies was developed. Ex vivo porcine vertebra experiments using a dMWA applicator measured temperatures approximately 10.1 mm radially from the applicator in the direction of MW radiation (T1) and approximately 2.4 mm in the contra-lateral direction (T2). Histologic assessment of ablated ex vivo tissue was conducted and experimental results compared to simulations. Pilot in vivo experiments in porcine vertebral bodies assessed ablation zones histologically and with CT and MRI.Results Experimental T1 and T2 temperatures were within 3–7% and 11–33% of simulated temperature values. Visible ablation zones, as indicated by grayed tissue, were smaller than those typical in other soft tissues. Posthumous MRI images of in vivo ablations showed hyperintensity. In vivo experiments illustrated the technical feasibility of creating directional microwave ablation zones in porcine vertebral body.Conclusion Computational models and experimental studies illustrate the feasibility of controlled dMWA in bone tissue. |
| format | Article |
| id | doaj-art-6dfb97fcea564010a1fc7e2bd7f5e542 |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-6dfb97fcea564010a1fc7e2bd7f5e5422025-01-03T09:30:28ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2024.2313492Directional microwave ablation in spine: experimental assessment of computational modelingAustin Pfannenstiel0Haileigh Avellar1Clay Hallman2Brandon L. Plattner3Margaret A. Highland4Francois H. Cornelis5Warren L. Beard6Punit Prakash7Precision Microwave Inc, Manhattan, KS, USADepartment of Clinical Sciences, Kansas State University, Manhattan, KS, USADepartment of Clinical Sciences, Kansas State University, Manhattan, KS, USADepartment of Diagnostic Medicine/Pathobiology and Kansas State Veterinary Diagnostic Laboratory, Kansas State University, Manhattan, KS, USAWI Veterinary Diagnostic Laboratory, University of Wisconsin-Madison, Madison, WI, USAInterventional Radiology Service, Memorial Sloan Kettering Cancer Center, NY, NY, USADepartment of Clinical Sciences, Kansas State University, Manhattan, KS, USADepartment of Electrical and Computer Engineering, KS State University, Manhattan, KS, USABackground Despite the theoretical advantages of treating metastatic bone disease with microwave ablation (MWA), there are few reports characterizing microwave absorption and bioheat transfer in bone. This report describes a computational modeling-based approach to simulate directional microwave ablation (dMWA) in spine, supported by ex vivo and pilot in vivo experiments in porcine vertebral bodies.Materials and methods A 3D computational model of microwave ablation within porcine vertebral bodies was developed. Ex vivo porcine vertebra experiments using a dMWA applicator measured temperatures approximately 10.1 mm radially from the applicator in the direction of MW radiation (T1) and approximately 2.4 mm in the contra-lateral direction (T2). Histologic assessment of ablated ex vivo tissue was conducted and experimental results compared to simulations. Pilot in vivo experiments in porcine vertebral bodies assessed ablation zones histologically and with CT and MRI.Results Experimental T1 and T2 temperatures were within 3–7% and 11–33% of simulated temperature values. Visible ablation zones, as indicated by grayed tissue, were smaller than those typical in other soft tissues. Posthumous MRI images of in vivo ablations showed hyperintensity. In vivo experiments illustrated the technical feasibility of creating directional microwave ablation zones in porcine vertebral body.Conclusion Computational models and experimental studies illustrate the feasibility of controlled dMWA in bone tissue.https://www.tandfonline.com/doi/10.1080/02656736.2024.2313492Microwave ablationbone ablationbone tumorthermal ablationdirectional antenna |
| spellingShingle | Austin Pfannenstiel Haileigh Avellar Clay Hallman Brandon L. Plattner Margaret A. Highland Francois H. Cornelis Warren L. Beard Punit Prakash Directional microwave ablation in spine: experimental assessment of computational modeling International Journal of Hyperthermia Microwave ablation bone ablation bone tumor thermal ablation directional antenna |
| title | Directional microwave ablation in spine: experimental assessment of computational modeling |
| title_full | Directional microwave ablation in spine: experimental assessment of computational modeling |
| title_fullStr | Directional microwave ablation in spine: experimental assessment of computational modeling |
| title_full_unstemmed | Directional microwave ablation in spine: experimental assessment of computational modeling |
| title_short | Directional microwave ablation in spine: experimental assessment of computational modeling |
| title_sort | directional microwave ablation in spine experimental assessment of computational modeling |
| topic | Microwave ablation bone ablation bone tumor thermal ablation directional antenna |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2313492 |
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