Production technologies and formulation strategies in development of orodispersible tablets (ODTs)
One of the new ways of drug delivery that is being developed more and more often recently is orodispersible tablets (ODTs), also known as orally disintegrating tablets, rapidly dissolving tablets and fast-dissolving tablets. The European Pharmacopoeia (Ph. Eur.) defines ODTs as uncoated tablets in...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical Association
2024-12-01
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| Series: | Makedonsko Farmacevtski Bilten |
| Subjects: | |
| Online Access: | https://bulletin.mfd.org.mk/volumes/Volume%2069_2/69_2_004.pdf |
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| Summary: | One of the new ways of drug delivery that is being developed more and more often recently is orodispersible tablets (ODTs), also
known as orally disintegrating tablets, rapidly dissolving tablets and fast-dissolving tablets. The European Pharmacopoeia (Ph. Eur.) defines
ODTs as uncoated tablets intended to be placed in the mouth where they disperse rapidly before swallowing, disintegrating within 3
minutes. ODTs come with many advantages such as: easy swallowability especially for paediatric, geriatric and bedridden patients, аs well
as for people with lack of access to water; fast release of API and fast onset of action; and enhanced bioavailability. Мany of the novel
drug delivery systems are difficult to scale-up and adapt to industrial production, and one of the many benefits of ODTs is that there are
ways to manufacture them with conventional technology, which makes them cost-effective. All of these advantages lead to improved
patient compliance. This review discusses the advantages and disadvantages of ODTs, the available production technologies including
patented technologies, the main challenges in formulation of ODTs and different approaches for solving them, and where the research into
ODTs as a novel drug delivery system is headed. |
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| ISSN: | 1857-8969 |