Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans
Abstract During memory formation, the hippocampus is presumed to represent the content of stimuli, but how it does so is unknown. Using computational modelling and human single-neuron recordings, we show that the more precisely hippocampal spiking variability tracks the composite features of each in...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-55406-4 |
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| _version_ | 1841559286810935296 |
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| author | Leonhard Waschke Fabian Kamp Evi van den Elzen Suresh Krishna Ulman Lindenberger Ueli Rutishauser Douglas D. Garrett |
| author_facet | Leonhard Waschke Fabian Kamp Evi van den Elzen Suresh Krishna Ulman Lindenberger Ueli Rutishauser Douglas D. Garrett |
| author_sort | Leonhard Waschke |
| collection | DOAJ |
| description | Abstract During memory formation, the hippocampus is presumed to represent the content of stimuli, but how it does so is unknown. Using computational modelling and human single-neuron recordings, we show that the more precisely hippocampal spiking variability tracks the composite features of each individual stimulus, the better those stimuli are later remembered. We propose that moment-to-moment spiking variability may provide a new window into how the hippocampus constructs memories from the building blocks of our sensory world. |
| format | Article |
| id | doaj-art-6d23c90598a341238c3f704efadd174e |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-6d23c90598a341238c3f704efadd174e2025-01-05T12:37:50ZengNature PortfolioNature Communications2041-17232025-01-011611910.1038/s41467-024-55406-4Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humansLeonhard Waschke0Fabian Kamp1Evi van den Elzen2Suresh Krishna3Ulman Lindenberger4Ueli Rutishauser5Douglas D. Garrett6Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Max Planck Institute for Human DevelopmentMax Planck UCL Centre for Computational Psychiatry and Ageing Research, Max Planck Institute for Human DevelopmentTilburg School of Social and Behavioral Sciences, Tilburg UniversityDepartment of Physiology, McGill UniversityMax Planck UCL Centre for Computational Psychiatry and Ageing Research, Max Planck Institute for Human DevelopmentDepartment of Neurosurgery, Cedars-Sinai Medical CenterMax Planck UCL Centre for Computational Psychiatry and Ageing Research, Max Planck Institute for Human DevelopmentAbstract During memory formation, the hippocampus is presumed to represent the content of stimuli, but how it does so is unknown. Using computational modelling and human single-neuron recordings, we show that the more precisely hippocampal spiking variability tracks the composite features of each individual stimulus, the better those stimuli are later remembered. We propose that moment-to-moment spiking variability may provide a new window into how the hippocampus constructs memories from the building blocks of our sensory world.https://doi.org/10.1038/s41467-024-55406-4 |
| spellingShingle | Leonhard Waschke Fabian Kamp Evi van den Elzen Suresh Krishna Ulman Lindenberger Ueli Rutishauser Douglas D. Garrett Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans Nature Communications |
| title | Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans |
| title_full | Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans |
| title_fullStr | Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans |
| title_full_unstemmed | Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans |
| title_short | Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans |
| title_sort | single neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans |
| url | https://doi.org/10.1038/s41467-024-55406-4 |
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