Structural and functional insights of sortases and their interactions with antivirulence compounds

Structural and functional insights of sortases and their interactions with antivirulence compounds

Sortase proteins play a crucial role as integral membrane proteins in anchoring bacterial surface proteins by recognizing them through a Cell-Wall Sorting (CWS) motif and cleaving them at specific sites before initiating pilus assembly. Both sortases and their substrate proteins are major virulence...

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Bibliographic Details
Main Authors: Sowmiya Sri Sivaramalingam, Deepsikha Jothivel, Deenadayalan Karaiyagowder Govindarajan, Lohita Kadirvelu, Muthusaravanan Sivaramakrishnan, Dhivia Dharshika Chithiraiselvan, Kumaravel Kandaswamy
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Current Research in Structural Biology
Subjects:
Sortases
Virulence
Pathogens
Inhibitors
Bacterial surface proteins
Online Access:http://www.sciencedirect.com/science/article/pii/S2665928X24000291
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