A bioanalytical method development and validation for quantification of glycopyrrolate and neostigmine in rat plasma by LC-MS and its application to pharmacokinetic study

A bioanalytical method development and validation for quantification of glycopyrrolate and neostigmine in rat plasma by LC-MS and its application to pharmacokinetic study

Background: After surgery, non-depolarizing neuromuscular blocking medications include neostigmine (NEO) and glycopyrrolate (GLY). Numerous traditional approaches, such as HPLC and UPLC procedures, are established for the quantification of GLY and NEO; nevertheless, they lack sensitive and specific...

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Bibliographic Details
Main Authors: P. Vasu Babu, D. Akiladevi
Format: Article
Language:English
Published: Creative Pharma Assent 2025-06-01
Series:Journal of Applied Pharmaceutical Research
Subjects:
lc-ms
glycopyrrolate
neostigmine
pharmacokinetics studies
Online Access:https://japtronline.com/index.php/joapr/article/view/834
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