Intermittent theta burst stimulation for negative symptoms in schizophrenia patients with mild cognitive impairment: a randomized controlled trail
BackgroundThis study aims to evaluate the intervention effect of intermittent Theta burst stimulation (iTBS) on bilateral dorsomedial prefrontal cortex (DMPFC) for negative symptoms in schizophrenia using functional near-infrared spectroscopy (fNIRS) to confirm the therapeutic significance of DMPFC...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1500113/full |
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| author | Jing Li Xian Mo Dan Jiang Xinyu Huang Xiao Wang Tingting Xia Wei Zhang Wei Zhang Wei Zhang |
| author_facet | Jing Li Xian Mo Dan Jiang Xinyu Huang Xiao Wang Tingting Xia Wei Zhang Wei Zhang Wei Zhang |
| author_sort | Jing Li |
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| description | BackgroundThis study aims to evaluate the intervention effect of intermittent Theta burst stimulation (iTBS) on bilateral dorsomedial prefrontal cortex (DMPFC) for negative symptoms in schizophrenia using functional near-infrared spectroscopy (fNIRS) to confirm the therapeutic significance of DMPFC in treating negative symptoms and provide new evidence for schizophrenia treatment and research.MethodThirty-nine schizophrenia patients with negative symptoms and mild cognitive impairment were randomly divided into a treatment group (n=20) and a control group (n=19). The treatment group received iTBS in bilateral DMPFC. The control group received the sham treatment. Negative symptoms, cognitive function, emotional state, and social function were assessed at pre-treatment, post-treatment, 4-, 8-, and 12-week follow-ups. Brain activation in regions of interest (ROIs) was evaluated through verbal fluency tasks. Changes in scale scores were analyzed by repeated measures ANOVA.ResultAfter 20 sessions of iTBS, the Scale for the Assessment of Negative Symptoms (SANS) total and sub-scale scores significantly improved in the treatment group, with statistically significant differences. SANS scores differed significantly between pre- and post-treatment in both groups, with post-treatment scores markedly lower than pre-treatment and better efficacy in the treatment group. However, there was no significant difference in cognitive function, emotional state, and social function. ROIs did not differ significantly between groups before intervention. After treatment, prefrontal cortex activation was significantly higher in the treatment group than in controls, with a statistically significant difference. Regarding functional connectivity, the small-world properties Sigma and Gamma were enhanced.ConclusioniTBS on bilateral DMPFC can effectively alleviate negative symptoms and enhance prefrontal cortex activation and the small-world properties in patients of schizophrenia. |
| format | Article |
| id | doaj-art-6c969e061ea04066a9a154c6303171fd |
| institution | Kabale University |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj-art-6c969e061ea04066a9a154c6303171fd2025-01-03T06:47:34ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-01-011510.3389/fpsyt.2024.15001131500113Intermittent theta burst stimulation for negative symptoms in schizophrenia patients with mild cognitive impairment: a randomized controlled trailJing Li0Xian Mo1Dan Jiang2Xinyu Huang3Xiao Wang4Tingting Xia5Wei Zhang6Wei Zhang7Wei Zhang8Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaBig Data Center, Sichuan University, Chengdu, ChinaPsychiatry Department, Jinxin Mental Hospital, Chengdu, Sichuan, ChinaPsychiatry Department, Jinxin Mental Hospital, Chengdu, Sichuan, ChinaPsychiatry Department, Jinxin Mental Hospital, Chengdu, Sichuan, ChinaPsychiatry Department, Jinxin Mental Hospital, Chengdu, Sichuan, ChinaMental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaBig Data Center, Sichuan University, Chengdu, ChinaWest China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, ChinaBackgroundThis study aims to evaluate the intervention effect of intermittent Theta burst stimulation (iTBS) on bilateral dorsomedial prefrontal cortex (DMPFC) for negative symptoms in schizophrenia using functional near-infrared spectroscopy (fNIRS) to confirm the therapeutic significance of DMPFC in treating negative symptoms and provide new evidence for schizophrenia treatment and research.MethodThirty-nine schizophrenia patients with negative symptoms and mild cognitive impairment were randomly divided into a treatment group (n=20) and a control group (n=19). The treatment group received iTBS in bilateral DMPFC. The control group received the sham treatment. Negative symptoms, cognitive function, emotional state, and social function were assessed at pre-treatment, post-treatment, 4-, 8-, and 12-week follow-ups. Brain activation in regions of interest (ROIs) was evaluated through verbal fluency tasks. Changes in scale scores were analyzed by repeated measures ANOVA.ResultAfter 20 sessions of iTBS, the Scale for the Assessment of Negative Symptoms (SANS) total and sub-scale scores significantly improved in the treatment group, with statistically significant differences. SANS scores differed significantly between pre- and post-treatment in both groups, with post-treatment scores markedly lower than pre-treatment and better efficacy in the treatment group. However, there was no significant difference in cognitive function, emotional state, and social function. ROIs did not differ significantly between groups before intervention. After treatment, prefrontal cortex activation was significantly higher in the treatment group than in controls, with a statistically significant difference. Regarding functional connectivity, the small-world properties Sigma and Gamma were enhanced.ConclusioniTBS on bilateral DMPFC can effectively alleviate negative symptoms and enhance prefrontal cortex activation and the small-world properties in patients of schizophrenia.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1500113/fullintermittent theta burst stimulation (iTBS)negative symptomsschizophreniadorsomedial prefrontal cortex (DMPFC)functional near-infrared spectroscopy (fNIRS) |
| spellingShingle | Jing Li Xian Mo Dan Jiang Xinyu Huang Xiao Wang Tingting Xia Wei Zhang Wei Zhang Wei Zhang Intermittent theta burst stimulation for negative symptoms in schizophrenia patients with mild cognitive impairment: a randomized controlled trail Frontiers in Psychiatry intermittent theta burst stimulation (iTBS) negative symptoms schizophrenia dorsomedial prefrontal cortex (DMPFC) functional near-infrared spectroscopy (fNIRS) |
| title | Intermittent theta burst stimulation for negative symptoms in schizophrenia patients with mild cognitive impairment: a randomized controlled trail |
| title_full | Intermittent theta burst stimulation for negative symptoms in schizophrenia patients with mild cognitive impairment: a randomized controlled trail |
| title_fullStr | Intermittent theta burst stimulation for negative symptoms in schizophrenia patients with mild cognitive impairment: a randomized controlled trail |
| title_full_unstemmed | Intermittent theta burst stimulation for negative symptoms in schizophrenia patients with mild cognitive impairment: a randomized controlled trail |
| title_short | Intermittent theta burst stimulation for negative symptoms in schizophrenia patients with mild cognitive impairment: a randomized controlled trail |
| title_sort | intermittent theta burst stimulation for negative symptoms in schizophrenia patients with mild cognitive impairment a randomized controlled trail |
| topic | intermittent theta burst stimulation (iTBS) negative symptoms schizophrenia dorsomedial prefrontal cortex (DMPFC) functional near-infrared spectroscopy (fNIRS) |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1500113/full |
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