Increased exacerbations and hospitalizations among PI*MZ compared to PI*MM individuals: an electronic health record analysis

Increased exacerbations and hospitalizations among PI*MZ compared to PI*MM individuals: an electronic health record analysis

Abstract Background The best described endotype of COPD is alpha-1 antitrypsin (AAT) deficiency, due to a genetic abnormality in the SERPINA1 gene. Common deficient PI variants are the Z and S variants. Homozygotes for the Z allele (PI*ZZ individuals) carry the genotype most commonly associated with...

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Main Authors: Vickram Tejwani, Yifan Wang, Lauren Munoz Tremblay, Elizabeth Azzato, Arianne K. Baldomero, Christine Wendt, Amy Attaway, Russell Bowler, Umur Hatipoglu, Rebecca Hutton, Charlie Strange, Xiaofeng Wang, Victor E. Ortega, Joe Zein, James K. Stoller
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Respiratory Research
Subjects:
Alpha-1 antitrypsin
COPD
Exacerbations
Healthcare utilizations
Online Access:https://doi.org/10.1186/s12931-025-03322-6
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https://doi.org/10.1186/s12931-025-03322-6

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