Dehydrocostus lactone suppresses gastric cancer progression by targeting ACLY to inhibit fatty acid synthesis and autophagic flux

Dehydrocostus lactone suppresses gastric cancer progression by targeting ACLY to inhibit fatty acid synthesis and autophagic flux

Introduction: Dehydrocostus lactone (Dehy), a natural sesquiterpene lactone from Saussurea lappa Clarke, displays remarkable efficacy in treating cancer and gastrointestinal disorders. However, its anti-gastric cancer (GC) effect remains poorly understood. Objectives: Our study aimed to elucidate th...

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Bibliographic Details
Main Authors:	Yuxuan Chen, Junyu Shen, Mengyun Yuan, Huaizhi Li, Yaqi Li, Shanshan Zheng, Bo Han, Cancan Zhang, Shenlin Liu, Qingmin Sun, Jian Wu
Format:	Article
Language:	English
Published:	Elsevier 2025-01-01
Series:	Journal of Advanced Research
Subjects:	Dehydrocostus lactone Gastric cancer ACLY Lipid metabolism Autophagy Ubiquitination
Online Access:	http://www.sciencedirect.com/science/article/pii/S2090123224000407
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