ETV2 transcriptionally activates Rig1 gene expression and promotes reprogramming of the endothelial lineage

ETV2 transcriptionally activates Rig1 gene expression and promotes reprogramming of the endothelial lineage

Abstract ETV2 is an essential transcription factor as Etv2 null murine embryos lack all vasculature, blood and are lethal early during embryogenesis. Previous studies have established that ETV2 functions as a pioneer factor and directly reprograms fibroblasts to endothelial cells. However, the under...

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Bibliographic Details
Main Authors: Young Geun Choi, Xiao Ma, Satyabrata Das, Javier E. Sierra-Pagan, Thijs Larson, Wuming Gong, Hesham A. Sadek, Jianyi (Jay) Zhang, Mary G. Garry, Daniel J. Garry
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
ETV2
RIG1
Reprogramming
Online Access:https://doi.org/10.1038/s41598-024-78115-w
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https://doi.org/10.1038/s41598-024-78115-w

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