Mathematical model of RNA-directed DNA methylation predicts tuning of negative feedback required for stable maintenance

RNA-directed DNA methylation (RdDM) is a plant-specific de novo methylation pathway that is responsible for maintenance of asymmetric methylation (CHH, H = A, T or G) in euchromatin. Loci with CHH methylation produce 24 nucleotide (nt) short interfering (si) RNAs. These siRNAs direct additional CHH...

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Bibliographic Details
Main Authors: Renee Dale, Rebecca Mosher
Format: Article
Language:English
Published: The Royal Society 2024-11-01
Series:Open Biology
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Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.240159
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