A vaccine targeting lung resident-memory CD4+ T cell phenotype protects against Mycobacterium tuberculosis in mice

A vaccine targeting lung resident-memory CD4+ T cell phenotype protects against Mycobacterium tuberculosis in mice

Abstract Lung-resident memory T (TRM) cells respond rapidly and effectively to respiratory pathogen invasion, suppressing pathogen proliferation. Previously, we identified a defined TLR3 agonist called Nexavant (NVT) and developed a vaccine platform that utilizes it to induce lung TRM. In this study...

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Main Authors: Kwang Hyun Ko, Seung-Hun Baek, Hyun Shik Bae, Young Mi Kim, Sun Hwa Gu, Yu Yeon Jung, Eun Hye Kwak, Han-Gyu Choi, Hwa-Jung Kim, Tae Sun Shim, Dong-Ho Kim, Seung Bin Cha
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01225-7
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