A Novel RAGE Modulator Induces Soluble RAGE to Reduce BACE1 Expression in Alzheimer's Disease

A Novel RAGE Modulator Induces Soluble RAGE to Reduce BACE1 Expression in Alzheimer's Disease

Abstract β‐secretase (BACE1) is instrumental in amyloid‐β (Aβ) production, with overexpression noted in Alzheimer's disease (AD) neuropathology. The interaction of Aβ with the receptor for advanced glycation endproducts (RAGE) facilitates cerebral uptake of Aβ and exacerbates its neurotoxicity...

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Main Authors: Seung‐Hyun Baek, Suji Hong, Eunae Kim, Sunyoung Park, Minyoung Lee, Jinsu Park, Yoonsuk Cho, Hyunjun Yoon, Daeseung Kim, Youngkwang Yun, Youbin Kim, Yoonjung Choi, Keunsoo Kang, Sangyong Jung, Jun Pyo Kim, Eunha Kim, Sang Won Seo, Yong‐Keun Jung, Dong‐Gyu Jo
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Advanced Science
Subjects:
6‐Thioguanosine (6‐TG)
Alzheimer's disease (AD)
amyloid‐β (Aβ)
BACE1
deep learning
drug repurposing
Online Access:https://doi.org/10.1002/advs.202407812
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https://doi.org/10.1002/advs.202407812

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