Mucinous lesions of the appendix: a histopathological study
Background: Mucinous lesions of the appendix are frequently misinterpreted in histopathological examination due to their relative rarity. Our study focuses on interpreting the histopathological spectrum of such lesions and understanding the disease burden of appendiceal mucinous lesions in a tertiar...
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Association of Clinical Pathologists of Nepal
2022-03-01
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| Series: | Journal of Pathology of Nepal |
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| Online Access: | https://www.nepjol.info/index.php/JPN/article/view/39338 |
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| author | Oshan Shrestha Reetu Baral |
| author_facet | Oshan Shrestha Reetu Baral |
| author_sort | Oshan Shrestha |
| collection | DOAJ |
| description | Background: Mucinous lesions of the appendix are frequently misinterpreted in histopathological examination due to their relative rarity. Our study focuses on interpreting the histopathological spectrum of such lesions and understanding the disease burden of appendiceal mucinous lesions in a tertiary centre.
Materials and Methods: This was a retrospective cross-sectional study conducted in the Department of Pathology. Gross and microscopic findings of appendicectomy specimens with mucinous lesions were analysed and classified according to the latest WHO 2019 recommendation.
Results: Seven hundred and forty appendicectomy specimens were received during the study period out of which nine appendix (1.2%) had mucinous lesions. Five (55.6%) of these lesions had a mucinous neoplasm while four of them (44.4%) were non-neoplastic. The most common lesion was low-grade appendiceal mucinous neoplasm (n=4; 44.4%). Two cases (22.2%) were retention cysts and there was one case each of mucinous adenocarcinoma, appendiceal diverticulosis, and endometriosis-associated mucinous metaplasia of the appendix. The mucinous neoplasms were significantly more common in females (80%). High-grade appendiceal mucinous neoplasms and serrated lesions or polyps weren’t seen in our study.
Conclusions: Mucinous lesions of the appendix are often incidental findings in patients operated for symptoms of acute appendicitis. Low-grade appendiceal mucinous neoplasms are the most common among them. Thorough knowledge of the neoplastic mimics and careful gross, as well as microscopic examination, is a must for proper diagnosis and staging since it has a significant impact on further patient management and prognostication. |
| format | Article |
| id | doaj-art-6bb136515bc34d39b1a528a5db7d73a6 |
| institution | Kabale University |
| issn | 2091-0797 2091-0908 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Association of Clinical Pathologists of Nepal |
| record_format | Article |
| series | Journal of Pathology of Nepal |
| spelling | doaj-art-6bb136515bc34d39b1a528a5db7d73a62025-08-21T07:06:58ZengAssociation of Clinical Pathologists of NepalJournal of Pathology of Nepal2091-07972091-09082022-03-011211893189910.3126/jpn.v12i1.3933866383Mucinous lesions of the appendix: a histopathological studyOshan Shrestha0https://orcid.org/0000-0003-1654-6107Reetu Baral1Nobel Medical College Teaching Hospital, Biratnagar, NepalNobel Medical College and Teaching Hospital, Biratnagar, NepalBackground: Mucinous lesions of the appendix are frequently misinterpreted in histopathological examination due to their relative rarity. Our study focuses on interpreting the histopathological spectrum of such lesions and understanding the disease burden of appendiceal mucinous lesions in a tertiary centre. Materials and Methods: This was a retrospective cross-sectional study conducted in the Department of Pathology. Gross and microscopic findings of appendicectomy specimens with mucinous lesions were analysed and classified according to the latest WHO 2019 recommendation. Results: Seven hundred and forty appendicectomy specimens were received during the study period out of which nine appendix (1.2%) had mucinous lesions. Five (55.6%) of these lesions had a mucinous neoplasm while four of them (44.4%) were non-neoplastic. The most common lesion was low-grade appendiceal mucinous neoplasm (n=4; 44.4%). Two cases (22.2%) were retention cysts and there was one case each of mucinous adenocarcinoma, appendiceal diverticulosis, and endometriosis-associated mucinous metaplasia of the appendix. The mucinous neoplasms were significantly more common in females (80%). High-grade appendiceal mucinous neoplasms and serrated lesions or polyps weren’t seen in our study. Conclusions: Mucinous lesions of the appendix are often incidental findings in patients operated for symptoms of acute appendicitis. Low-grade appendiceal mucinous neoplasms are the most common among them. Thorough knowledge of the neoplastic mimics and careful gross, as well as microscopic examination, is a must for proper diagnosis and staging since it has a significant impact on further patient management and prognostication.https://www.nepjol.info/index.php/JPN/article/view/39338appendixmimicsmucinous neoplasms |
| spellingShingle | Oshan Shrestha Reetu Baral Mucinous lesions of the appendix: a histopathological study Journal of Pathology of Nepal appendix mimics mucinous neoplasms |
| title | Mucinous lesions of the appendix: a histopathological study |
| title_full | Mucinous lesions of the appendix: a histopathological study |
| title_fullStr | Mucinous lesions of the appendix: a histopathological study |
| title_full_unstemmed | Mucinous lesions of the appendix: a histopathological study |
| title_short | Mucinous lesions of the appendix: a histopathological study |
| title_sort | mucinous lesions of the appendix a histopathological study |
| topic | appendix mimics mucinous neoplasms |
| url | https://www.nepjol.info/index.php/JPN/article/view/39338 |
| work_keys_str_mv | AT oshanshrestha mucinouslesionsoftheappendixahistopathologicalstudy AT reetubaral mucinouslesionsoftheappendixahistopathologicalstudy |