Verteporfin inhibits the cGAS-STING pathway and improves the tumor microenvironment during cisplatin treatment in hepatocellular carcinoma

Verteporfin inhibits the cGAS-STING pathway and improves the tumor microenvironment during cisplatin treatment in hepatocellular carcinoma

BackgroundCisplatin (DDP) is a clinical first-line chemotherapy drug for hepatocellular carcinoma (HCC), but treatment is often ineffective due to drug resistance. Yes-associated protein 1 (YAP1) is a critical regulator/factor in HCC tumor progression. Our previous research showed that DDP promoted...

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Bibliographic Details
Main Authors: Yi Gong, Yajun Xiong, Yuting Gao, Xiaoyong Song, Yanli Gong, Dan Wang, Zhihan Liu, Yanguang Yang, Junlan Lu, Isabelle Xinyue Zou, Xinli Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
cisplatin
Yap1
hepatocellular carcinoma
PD-1
CGAS
STING
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1658042/full
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