Pharmacological relevance of taraxasterol: A review
Introduction: Taraxasterol is a pentacyclic triterpenoid which was first discovered from the roots of Taraxacum officinale. However, it is generally found in the Taraxacum genus (Pugongying in Chinese). It has been reported to possess several medicinal properties, and modulate several biochemical an...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Pharmacological Research - Modern Chinese Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667142524001751 |
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| author | Olabisi Tajudeen Obafemi Ademola Olabode Ayeleso Blessing Ariyo Obafemi Olusola Bolaji Adewale Benjamin Olusola Omiyale Sogolo Lucky Lebelo Monde McMillan Ntwasa |
| author_facet | Olabisi Tajudeen Obafemi Ademola Olabode Ayeleso Blessing Ariyo Obafemi Olusola Bolaji Adewale Benjamin Olusola Omiyale Sogolo Lucky Lebelo Monde McMillan Ntwasa |
| author_sort | Olabisi Tajudeen Obafemi |
| collection | DOAJ |
| description | Introduction: Taraxasterol is a pentacyclic triterpenoid which was first discovered from the roots of Taraxacum officinale. However, it is generally found in the Taraxacum genus (Pugongying in Chinese). It has been reported to possess several medicinal properties, and modulate several biochemical and metabolic signaling pathways as a means of exerting its pharmacological effects. Even though some biological effects have been ascribed to taraxasterol, it is still being explored for more therapeutic benefits. This review aimed to highlight the relevance of taraxasterol as an antidiabetic, anti-cancer, anti-inflammatory and an antioxidant agent. Methods: Articles for this review were searched on Scopus, Nature, SpringerLink and PubMed databases. The keywords used for the search were “taraxasterol pharmacology”, “taraxasterol antioxidant”, “taraxasterol cancer”, “taraxasterol biosynthesis” and “taraxasterol antidiabetic”. Relevance and report of distinct mechanisms of action were considered in the selection. Results: This review underlines the therapeutic potential of taraxasterol in cancer and diabetes conditions, while also highlighting its anti-inflammatory and antioxidant effects. Some specific biochemical pathways that are modulated due to the pharmacological effect of taraxasterol were diagrammatically represented. Conclusions: It is hoped that this review would stimulate interest in taraxasterol by focusing on its pharmacological relevance, specific mechanisms of action and pharmacokinetics. This might facilitate its eventual development into drug and adoption into treatment regimen of various diseases. |
| format | Article |
| id | doaj-art-6b446d00620a42c9a01da64b9c6703df |
| institution | Kabale University |
| issn | 2667-1425 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research - Modern Chinese Medicine |
| spelling | doaj-art-6b446d00620a42c9a01da64b9c6703df2024-12-19T11:02:23ZengElsevierPharmacological Research - Modern Chinese Medicine2667-14252024-12-0113100533Pharmacological relevance of taraxasterol: A reviewOlabisi Tajudeen Obafemi0Ademola Olabode Ayeleso1Blessing Ariyo Obafemi2Olusola Bolaji Adewale3Benjamin Olusola Omiyale4Sogolo Lucky Lebelo5Monde McMillan Ntwasa6Department of Life and Consumer Sciences, University of South Africa, Johannesburg 1709, South Africa; Corresponding author at: Department of Life and Consumer Sciences, University of South Africa, Johannesburg 1709, South Africa.Department of Life and Consumer Sciences, University of South Africa, Johannesburg 1709, South Africa; Biochemistry Programme, College of Agriculture, Engineering and Sciences, Bowen University, Iwo, PMB 284 Osun State, NigeriaDepartment of Medical Biochemistry, Afe Babalola University, Ado-Ekiti PMB 5454, NigeriaDepartment of Chemical Sciences, Afe Babalola University, Ado-Ekiti PMB 5454, NigeriaDepartment of Medical Biochemistry, Afe Babalola University, Ado-Ekiti PMB 5454, NigeriaDepartment of Life and Consumer Sciences, University of South Africa, Johannesburg 1709, South AfricaDepartment of Life and Consumer Sciences, University of South Africa, Johannesburg 1709, South AfricaIntroduction: Taraxasterol is a pentacyclic triterpenoid which was first discovered from the roots of Taraxacum officinale. However, it is generally found in the Taraxacum genus (Pugongying in Chinese). It has been reported to possess several medicinal properties, and modulate several biochemical and metabolic signaling pathways as a means of exerting its pharmacological effects. Even though some biological effects have been ascribed to taraxasterol, it is still being explored for more therapeutic benefits. This review aimed to highlight the relevance of taraxasterol as an antidiabetic, anti-cancer, anti-inflammatory and an antioxidant agent. Methods: Articles for this review were searched on Scopus, Nature, SpringerLink and PubMed databases. The keywords used for the search were “taraxasterol pharmacology”, “taraxasterol antioxidant”, “taraxasterol cancer”, “taraxasterol biosynthesis” and “taraxasterol antidiabetic”. Relevance and report of distinct mechanisms of action were considered in the selection. Results: This review underlines the therapeutic potential of taraxasterol in cancer and diabetes conditions, while also highlighting its anti-inflammatory and antioxidant effects. Some specific biochemical pathways that are modulated due to the pharmacological effect of taraxasterol were diagrammatically represented. Conclusions: It is hoped that this review would stimulate interest in taraxasterol by focusing on its pharmacological relevance, specific mechanisms of action and pharmacokinetics. This might facilitate its eventual development into drug and adoption into treatment regimen of various diseases.http://www.sciencedirect.com/science/article/pii/S2667142524001751TaraxasterolPharmacologicalDiseasesPathwaysMedicinal plants |
| spellingShingle | Olabisi Tajudeen Obafemi Ademola Olabode Ayeleso Blessing Ariyo Obafemi Olusola Bolaji Adewale Benjamin Olusola Omiyale Sogolo Lucky Lebelo Monde McMillan Ntwasa Pharmacological relevance of taraxasterol: A review Pharmacological Research - Modern Chinese Medicine Taraxasterol Pharmacological Diseases Pathways Medicinal plants |
| title | Pharmacological relevance of taraxasterol: A review |
| title_full | Pharmacological relevance of taraxasterol: A review |
| title_fullStr | Pharmacological relevance of taraxasterol: A review |
| title_full_unstemmed | Pharmacological relevance of taraxasterol: A review |
| title_short | Pharmacological relevance of taraxasterol: A review |
| title_sort | pharmacological relevance of taraxasterol a review |
| topic | Taraxasterol Pharmacological Diseases Pathways Medicinal plants |
| url | http://www.sciencedirect.com/science/article/pii/S2667142524001751 |
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