An O-glycopeptide participates in the formation of distinct Aβ42 fibril structures and attenuates Aβ42 neurotoxicity

An O-glycopeptide participates in the formation of distinct Aβ42 fibril structures and attenuates Aβ42 neurotoxicity

Abstract The self-assembly of biomolecules through noncovalent interactions is critical in both physiological and pathological processes, as exemplified by the assembly of amyloid β peptide (Aβ) into oligomers or fibrils in Alzheimer’s disease (AD). Developing molecules that can modulate this assemb...

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Main Authors: Qijia Wei, Dangliang Liu, Wencheng Xia, Fengzhang Wang, Lu Huang, Jun Zhang, Xiaoya Wang, Zhongxin Xu, Changdong He, Wenzhe Li, Xiaomeng Shi, Chu Wang, Yuan Liu, Cong Liu, Suwei Dong
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60978-w
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https://doi.org/10.1038/s41467-025-60978-w

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