Visual electrophysiological assessment of children with poor response to treatment for functional amblyopia
AIM: To assess the visual electrophysiological outcomes in children with functional amblyopia who exhibited poor response to conventional treatment. METHODS: Twenty-one children with functional amblyopia, aged 5.7±2.1y (range: 4-10y), underwent comprehensive ophthalmic and refractive evaluations. Sp...
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Press of International Journal of Ophthalmology (IJO PRESS)
2025-02-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2025/2/20250216.pdf |
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| author | Dong-Qing Yuan Wei-Wei Zhang Liu-Wei Gu Qing-Huai Liu |
| author_facet | Dong-Qing Yuan Wei-Wei Zhang Liu-Wei Gu Qing-Huai Liu |
| author_sort | Dong-Qing Yuan |
| collection | DOAJ |
| description | AIM: To assess the visual electrophysiological outcomes in children with functional amblyopia who exhibited poor response to conventional treatment. METHODS: Twenty-one children with functional amblyopia, aged 5.7±2.1y (range: 4-10y), underwent comprehensive ophthalmic and refractive evaluations. Spectral domain-optical coherence tomography (SD-OCT) and multifocal electroretinography (mfERG) were conducted to analyze the macular retinal thickness and the first-order response P1 ring of the mfERG in the amblyopic eye (AE) compared to the fellow good eye (GE). RESULTS: Initially, visual acuity in the AE ranged from 20/800 to 20/40, while the GE exhibited a range of 20/25 to 20/20 (P<0.01). After 6mo of treatment, 17 patients demonstrated improved visual acuity in the AE to 20/50 or better, while 4 children showed no improvement. SD-OCT revealed comparable macular and optic disc structures between the AE and GE. Prior to treatment, the mfERG P1 ring amplitude was significantly reduced in the AE compared to GE (P<0.05). The AE/GE ratio of P1 ring amplitude showed significant improvement post-treatment. However, a smaller AE/GE ratio before treatment was associated with poorer improvement post-treatment. CONCLUSION: In the management of functional amblyopia, a thorough assessment of amblyopic eye examinations is crucial. Approximately 20% of amblyopic eyes may not achieve significant improvement in visual acuity, despite the absence of detectable organic retinal abnormalities. mfERG may reveal underlying abnormalities. Integrating mfERG into initial assessments or treatment follow-ups can aid in identifying potential hidden retinal defects and predicting the prognosis of the amblyopic eye. |
| format | Article |
| id | doaj-art-6b0db600cc9b43e1bac960da130b137c |
| institution | Kabale University |
| issn | 2222-3959 2227-4898 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj-art-6b0db600cc9b43e1bac960da130b137c2025-01-16T07:54:35ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982025-02-0118231532210.18240/ijo.2025.02.1620250216Visual electrophysiological assessment of children with poor response to treatment for functional amblyopiaDong-Qing Yuan0Wei-Wei Zhang1Liu-Wei Gu2Qing-Huai Liu3Qing-Huai Liu. Department of Ophthalmology, Jiangsu Province Hospital (the First Affiliated Hospital of Nanjing Medical University), 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. liuqh@njmu.edu.cnDepartment of Ophthalmology, Jiangsu Province Hospital, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Women and Children Health Hospital, Nanjing 210029, Jiangsu Province, ChinaDepartment of Ophthalmology, Jiangsu Province Hospital, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Women and Children Health Hospital, Nanjing 210029, Jiangsu Province, ChinaDepartment of Ophthalmology, Jiangsu Province Hospital, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Women and Children Health Hospital, Nanjing 210029, Jiangsu Province, ChinaAIM: To assess the visual electrophysiological outcomes in children with functional amblyopia who exhibited poor response to conventional treatment. METHODS: Twenty-one children with functional amblyopia, aged 5.7±2.1y (range: 4-10y), underwent comprehensive ophthalmic and refractive evaluations. Spectral domain-optical coherence tomography (SD-OCT) and multifocal electroretinography (mfERG) were conducted to analyze the macular retinal thickness and the first-order response P1 ring of the mfERG in the amblyopic eye (AE) compared to the fellow good eye (GE). RESULTS: Initially, visual acuity in the AE ranged from 20/800 to 20/40, while the GE exhibited a range of 20/25 to 20/20 (P<0.01). After 6mo of treatment, 17 patients demonstrated improved visual acuity in the AE to 20/50 or better, while 4 children showed no improvement. SD-OCT revealed comparable macular and optic disc structures between the AE and GE. Prior to treatment, the mfERG P1 ring amplitude was significantly reduced in the AE compared to GE (P<0.05). The AE/GE ratio of P1 ring amplitude showed significant improvement post-treatment. However, a smaller AE/GE ratio before treatment was associated with poorer improvement post-treatment. CONCLUSION: In the management of functional amblyopia, a thorough assessment of amblyopic eye examinations is crucial. Approximately 20% of amblyopic eyes may not achieve significant improvement in visual acuity, despite the absence of detectable organic retinal abnormalities. mfERG may reveal underlying abnormalities. Integrating mfERG into initial assessments or treatment follow-ups can aid in identifying potential hidden retinal defects and predicting the prognosis of the amblyopic eye.http://ies.ijo.cn/en_publish/2025/2/20250216.pdffunctional amblyopiapoor responseoptical coherence tomographymultifocal electroretinographyretinal defects |
| spellingShingle | Dong-Qing Yuan Wei-Wei Zhang Liu-Wei Gu Qing-Huai Liu Visual electrophysiological assessment of children with poor response to treatment for functional amblyopia International Journal of Ophthalmology functional amblyopia poor response optical coherence tomography multifocal electroretinography retinal defects |
| title | Visual electrophysiological assessment of children with poor response to treatment for functional amblyopia |
| title_full | Visual electrophysiological assessment of children with poor response to treatment for functional amblyopia |
| title_fullStr | Visual electrophysiological assessment of children with poor response to treatment for functional amblyopia |
| title_full_unstemmed | Visual electrophysiological assessment of children with poor response to treatment for functional amblyopia |
| title_short | Visual electrophysiological assessment of children with poor response to treatment for functional amblyopia |
| title_sort | visual electrophysiological assessment of children with poor response to treatment for functional amblyopia |
| topic | functional amblyopia poor response optical coherence tomography multifocal electroretinography retinal defects |
| url | http://ies.ijo.cn/en_publish/2025/2/20250216.pdf |
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