Blood biomarkers are altered in elderly hematological patients exhibiting a mosaic loss of the Y chromosome in bone marrow cells

Blood biomarkers are altered in elderly hematological patients exhibiting a mosaic loss of the Y chromosome in bone marrow cells

Abstract Background Mosaic loss of the Y chromosome (LOY) is a frequent somatic alteration observed in aging males, linked to clonal hematopoiesis and elevated risks of hematologic malignancies. However, the direct physiological implications of LOY in elderly patients with hematologic disorders rema...

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Bibliographic Details
Main Authors: Lin Liu, Liangshun You, Huan Xu, Lu Wang, Shuqi Zhao, Hongyan Tong, Jie Jin
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Cancer
Subjects:
Mosaic loss of Y chromosome
Hematologic malignancies
Elderly patients
Clonal hematopoiesis
Biomarkers
Online Access:https://doi.org/10.1186/s12885-025-14584-0
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https://doi.org/10.1186/s12885-025-14584-0

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