Manipulating adenovirus hexon hypervariable loops dictates immune neutralisation and coagulation factor X-dependent cell interaction in vitro and in vivo.

Manipulating adenovirus hexon hypervariable loops dictates immune neutralisation and coagulation factor X-dependent cell interaction in vitro and in vivo.

Adenoviruses are common pathogens, mostly targeting ocular, gastrointestinal and respiratory cells, but in some cases infection disseminates, presenting in severe clinical outcomes. Upon dissemination and contact with blood, coagulation factor X (FX) interacts directly with the adenovirus type 5 (Ad...

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Main Authors: Jiangtao Ma, Margaret R Duffy, Lin Deng, Rachel S Dakin, Taco Uil, Jerome Custers, Sharon M Kelly, John H McVey, Stuart A Nicklin, Andrew H Baker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1004673
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https://doi.org/10.1371/journal.ppat.1004673

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