Inhibition of astrocyte signaling leads to sex-specific changes in microglia phenotypes in a diet-based model of cerebral small vessel disease

Inhibition of astrocyte signaling leads to sex-specific changes in microglia phenotypes in a diet-based model of cerebral small vessel disease

Abstract Hyperhomocysteinemia (HHcy)-inducing diets recapitulate cerebral small vessel disease phenotypes in mice including cerebrovascular pathology/dysfunction, neuroinflammation, synaptic deficits, and cognitive decline. We recently showed that astrocyte signaling through calcineurin(CN)/nuclear...

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Main Authors: Jenna L. Gollihue, Khine Zin Aung, Colin B. Rogers, Leopoldine B. Galopin, Nicholas A. Wright, Pradoldej Sompol, Erica M. Weekman, Yuriko Katsumata, Josh M. Morganti, Christopher M. Norris
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Neuroinflammation
Subjects:
Astrocyte reactivity
Neuroinflammation
Calcium
Vascular
Microglia
Online Access:https://doi.org/10.1186/s12974-025-03523-2
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https://doi.org/10.1186/s12974-025-03523-2

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