TNF induces catabolism in human cartilaginous endplate cells in 3D agarose culture under dynamic compression

TNF induces catabolism in human cartilaginous endplate cells in 3D agarose culture under dynamic compression

Abstract Intervertebral disc (IVD) degeneration is the leading cause of low back pain in young adults, and the cartilaginous endplate (CEP) is likely to play a key role in early IVD degeneration. To elucidate the effects of pro-inflammatory cytokines on the mechanobiology of the CEP, human CEP cells...

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Main Authors: Katherine B. Crump, Exarchos Kanelis, Maria Segarra-Queralt, Andreu Pascuet-Fontanet, Paola Bermudez-Lekerika, Ahmad Alminnawi, Liesbet Geris, Leonidas G. Alexopoulos, Jérôme Noailly, Benjamin Gantenbein
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Intervertebral disc
Cartilaginous endplate 3D culture
Agarose
Dynamic compression
Catabolism
Mechanobiology
Online Access:https://doi.org/10.1038/s41598-025-00538-w
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https://doi.org/10.1038/s41598-025-00538-w

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