Proliferative Verrucous Leukoplakia of the Gingiva: An Early Lesion Refractory to Surgical Excision
This report describes a case of proliferative verrucous leukoplakia (PVL) of the gingiva with no discernible aetiology, which presented in a 36-year-old female. The initial nonscrapable gingival lesion was treated with CO2 laser ablation, and the histopathological evaluation was carried out. The pre...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2019/5785060 |
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| author | Dhanushka Leuke Bandara Primali Rukmal Jayasooriya Ruwan Duminda Jayasinghe |
| author_facet | Dhanushka Leuke Bandara Primali Rukmal Jayasooriya Ruwan Duminda Jayasinghe |
| author_sort | Dhanushka Leuke Bandara |
| collection | DOAJ |
| description | This report describes a case of proliferative verrucous leukoplakia (PVL) of the gingiva with no discernible aetiology, which presented in a 36-year-old female. The initial nonscrapable gingival lesion was treated with CO2 laser ablation, and the histopathological evaluation was carried out. The presence of koilocytic cells in the superficial epithelium led to immunohistochemical investigations with p16 antibody, which showed strong nuclear positivity and slight cytoplasmic positivity in >50% of the cells with >25% confluency. However, it was not possible to confirm the presence of HPV infection with further investigations due to logistic reasons. The lesion recurred twice within a short time despite the surgical resection following the first recurrence. Thus, this paper presents a case of proliferative verrucous leukoplakia, which demonstrated a significant resistance to routine treatment protocols recommended in the management of such lesions. |
| format | Article |
| id | doaj-art-6a348e28d9074a61b5e1017988c5a2e1 |
| institution | Kabale University |
| issn | 2090-6447 2090-6455 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dentistry |
| spelling | doaj-art-6a348e28d9074a61b5e1017988c5a2e12025-02-03T05:47:26ZengWileyCase Reports in Dentistry2090-64472090-64552019-01-01201910.1155/2019/57850605785060Proliferative Verrucous Leukoplakia of the Gingiva: An Early Lesion Refractory to Surgical ExcisionDhanushka Leuke Bandara0Primali Rukmal Jayasooriya1Ruwan Duminda Jayasinghe2Department of Oral Medicine & Periodontology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya 20400, Sri LankaDepartment of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya 20400, Sri LankaDepartment of Oral Medicine & Periodontology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya 20400, Sri LankaThis report describes a case of proliferative verrucous leukoplakia (PVL) of the gingiva with no discernible aetiology, which presented in a 36-year-old female. The initial nonscrapable gingival lesion was treated with CO2 laser ablation, and the histopathological evaluation was carried out. The presence of koilocytic cells in the superficial epithelium led to immunohistochemical investigations with p16 antibody, which showed strong nuclear positivity and slight cytoplasmic positivity in >50% of the cells with >25% confluency. However, it was not possible to confirm the presence of HPV infection with further investigations due to logistic reasons. The lesion recurred twice within a short time despite the surgical resection following the first recurrence. Thus, this paper presents a case of proliferative verrucous leukoplakia, which demonstrated a significant resistance to routine treatment protocols recommended in the management of such lesions.http://dx.doi.org/10.1155/2019/5785060 |
| spellingShingle | Dhanushka Leuke Bandara Primali Rukmal Jayasooriya Ruwan Duminda Jayasinghe Proliferative Verrucous Leukoplakia of the Gingiva: An Early Lesion Refractory to Surgical Excision Case Reports in Dentistry |
| title | Proliferative Verrucous Leukoplakia of the Gingiva: An Early Lesion Refractory to Surgical Excision |
| title_full | Proliferative Verrucous Leukoplakia of the Gingiva: An Early Lesion Refractory to Surgical Excision |
| title_fullStr | Proliferative Verrucous Leukoplakia of the Gingiva: An Early Lesion Refractory to Surgical Excision |
| title_full_unstemmed | Proliferative Verrucous Leukoplakia of the Gingiva: An Early Lesion Refractory to Surgical Excision |
| title_short | Proliferative Verrucous Leukoplakia of the Gingiva: An Early Lesion Refractory to Surgical Excision |
| title_sort | proliferative verrucous leukoplakia of the gingiva an early lesion refractory to surgical excision |
| url | http://dx.doi.org/10.1155/2019/5785060 |
| work_keys_str_mv | AT dhanushkaleukebandara proliferativeverrucousleukoplakiaofthegingivaanearlylesionrefractorytosurgicalexcision AT primalirukmaljayasooriya proliferativeverrucousleukoplakiaofthegingivaanearlylesionrefractorytosurgicalexcision AT ruwandumindajayasinghe proliferativeverrucousleukoplakiaofthegingivaanearlylesionrefractorytosurgicalexcision |